My project focuses on developing new methodologies for quantifying interactions between neural populations from electrophysiology data.
Sensory systems are typically considered as hierarchically organized feed forward streams, such as the retino-geniculate pathway and its follow-up ventral and dorsal streams that pass information from thalamus to a large number of cortical areas. Yet, connectivity in cortex is strictly bidirectional, and for each pair of interconnected cortical regions there is also a parallel cortical-thalamo-cortical path. At a smaller spatial scale, the neural tissue is locally organized in microcircuits of strongly interconnected populations of inhibitory and excitatory neurons.
Understanding how information is processed in this highly recurrent brain network thus requires a fine quantification of its functional and causal interactions. To achieve this, I develop new statistical analysis techniques for neurophysiology data. In particular, I use information theory and kernel methods to detect dependencies in experimental time series.
For more information, please visit my homepage.
M. Besserve, N. Logothetis, B. Schölkopf
(2013). Statistical analysis of coupled time series with Kernel Cross-Spectral Density operators In: Advances in Neural Information Processing Systems 26, (Ed) C.J.C. Burges, L. Bottou, M. Welling, Z. Ghahramani, and K.Q. Weinberger, 2535–2543, 27th Annual Conference on Neural Information Processing Systems (NIPS 2013)
NK. Logothetis, O. Eschenko, Y. Murayama, M. Augath, T. Steudel, HC. Evrard, M. Besserve, A. Oeltermann
(2013). Studying large-scale brain networks: electrical stimulation and neural-event-triggered fMRI Keynote Lecture, Twenty-Second Annual Computational Neuroscience Meeting (CNS*2013)
D. Balduzzi, M. Besserve
(2012). Towards a learning-theoretic analysis of spike-timing dependent plasticity In: Advances in Neural Information Processing Systems 25, (Ed) P Bartlett and FCN Pereira and CJC. Burges and L Bottou and KQ Weinberger, Curran Associates Inc., 2465–2473, 26th Annual Conference on Neural Information Processing Systems (NIPS 2012)
T. Panagiotaropoulos, M. Besserve, B. Crocker, V. Kapoor, AS. Tolias, S. Panzeri, NK. Logothetis
(2011). Spatiotemporal mapping of rhythmic activity in the inferior convexity of the macaque prefrontal cortex 41, (239.15), 41st Annual Meeting of the Society for Neuroscience (Neuroscience 2011)