Brain-Computer Interfaces (BCIs) are systems that can translate brain activity patterns of a user into messages or commands for an interactive application. Such brain activity is typically measured using Electroencephalography (EEG), before being processed and classified by the system. EEG-based BCIs have proven promising for a wide range of applications ranging from communication and control for motor impaired users, to gaming targeted at the general public, real-time mental state monitoring and stroke rehabilitation, to name a few. Despite this promising potential, BCIs are still scarcely used outside laboratories for practical applications. The main reason preventing EEG-based BCIs from being widely used is arguably their poor usability, which is notably due to their low robustness and reliability, as well as their long training times. In this talk I present some of our research aimed at addressing these points in order to make EEG-based BCIs usable, i.e., to increase their efficacy and efficiency. In particular, I will present a set of contributions towards this goal 1) at the user training level, to ensure that users can learn to control a BCI efficiently and effectively, and 2) at the usage level, to explore novel applications of BCIs for which the current reliability can already be useful, e.g., for neuroergonomics or real-time brain activity and mental state visualization.
Coronary artery disease (CAD) is the single leading cause of death worldwide and Cardiac Computed Tomography Angiography (CCTA) is a non-invasive test to rule out CAD using the anatomical characterization of the coronary lesions. Recent studies suggest that coronary lesions’ hemodynamic significance can be assessed by Fractional Flow Reserve (FFR), which is usually measured invasively in the CathLab but can also be simulated from a patient-specific biophysical model based on CCTA data. We learn a parametric lumped model (LM) enabling fast computational fluid dynamic simulations of blood flow in elongated vessel networks to alleviate the computational burden of 3D finite element (FE) simulations. We adapt the coefficients balancing the local nonlinear hydraulic effects from a training set of precomputed FE simulations. Our LM yields accurate pressure predictions suggesting that costly FE simulations can be replaced by our fast LM paving the way to use a personalised interactive biophysical model with realtime feedback in clinical practice.
The development of increasingly intelligent and autonomous technologies will inevitably lead to these systems having to face morally problematic situations. This is particularly true of artificial systems that are used in geriatric care environments. It will, therefore, be necessary in the long run to develop machines which have the capacity for a certain amount of autonomous moral decision-making. The goal of this talk is to provide the theoretical foundations for artificial morality, i.e., for implementing moral capacities in artificial systems in general and a roadmap for developing an assistive system in geriatric care which is capable of moral learning.
The detection and characterization of planets orbiting other stars than the Sun, i.e., so-called extrasolar planets, is one of the fastest growing and most vibrant research fields in modern astrophysics. In the last 25 years, more than 5400 extrasolar planets and planet candidates were revealed, but the vast majority of these objects was detected with indirect techniques, where the existence of the planet is inferred from periodic changes in the light coming from the central star. No photons from the planets themselves are detected. In this talk, however, I will focus on the direct detection of extrasolar planets. On the one hand I will describe the main challenges that have to be overcome in order to image planets around other stars. In addition to using the world’s largest telescopes and optimized cameras it was realized in last few years that by applying advanced image processing techniques significant sensitivity gains can be achieved. On the other hand I will demonstrate what can be learned if one is successful in “taking a picture” of an extrasolar planet. After all, there must be good scientific reasons and a strong motivation why the direct detection of extrasolar planets is one of the key science drivers for current and future projects on major ground- and space-based telescopes.
Our research questions are centred on a basic characteristic of human brains: variability in their behaviour and their underlying meaning for cognitive mechanisms. Such variability is emerging as a key ingredient in understanding biological principles (Faisal, Selen & Wolpert, 2008, Nature Rev Neurosci) and yet lacks adequate quantitative and computational methods for description and analysis. Crucially, we find that biological and behavioural variability contains important information that our brain and our technology can make us of (instead of just averaging it away): Using advanced body sensor networks, we measured eye-movements, full-body and hand kinematics of humans living in a studio flat and are going to present some insightful results on motor control and visual attention that suggest that the control of behaviour "in-the-wild" is predictably different ways than what we measure "in-the-lab". The results have implications for robotics, prosthetics and neuroscience.
Organizers: Matthias Hohmann
Beginning with a seminal paper of Diaconis (1988), the aim of so-called "probabilistic numerics" is to compute probabilistic solutions to deterministic problems arising in numerical analysis by casting them as statistical inference problems. For example, numerical integration of a deterministic function can be seen as the integration of an unknown/random function, with evaluations of the integrand at the integration nodes proving partial information about the integrand. Advantages offered by this viewpoint include: access to the Bayesian representation of prior and posterior uncertainties; better propagation of uncertainty through hierarchical systems than simple worst-case error bounds; and appropriate accounting for numerical truncation and round-off error in inverse problems, so that the replicability of deterministic simulations is not confused with their accuracy, thereby yielding an inappropriately concentrated Bayesian posterior. This talk will describe recent work on probabilistic numerical solvers for ordinary and partial differential equations, including their theoretical construction, convergence rates, and applications to forward and inverse problems. Joint work with Andrew Stuart (Warwick).
Organizers: Philipp Hennig
More than half of the persons with spinal cord injuries (SCI) are suffering from impairments of both hands, which results in a tremendous decrease of quality of life and represents a major barrier for inclusion in society. Functional restoration is possible with neuroprostheses (NPs) based on functional electrical stimulation (FES). A Brain-Computer Interface provides a means of control for such neuroprosthetics since users have limited abilities to use traditional assistive devices. This talk presents our early research on BCI-based NP control based on motor imagery, discusses hybrid BCI solutions and shows our work and effort on movement trajectory decoding. An outlook to future BCI applications will conclude this talk.
Organizers: Moritz Grosse-Wentrup
During rest, brain activity is intrinsically synchronized between different brain regions, forming networks of coherent activity. These functional networks (FNs), consisting of multiple regions widely distributed across lobes and hemispheres, appear to be a fundamental theme of neural organization in mammalian brains. Despite hundreds of studies detailing this phenomenon, the genetic and molecular mechanisms supporting these functional networks remain undefined. Previous work has mostly focused on polymorphisms in candidate genes, or used a twin study approach to demonstrate heritability of aspects of resting-state connectivity. The recent availability of high spatial resolution post-mortem brain gene expression datasets, together with several large-scale imaging genetics datasets, which contain joint in-vivo functional brain imaging data and genotype data for several hundred subjects, opens intriguing data analysis avenues. Using novel cross-modal graph-based statistics, we show that functional brain networks defined with resting-state fMRI can be recapitulated using measures of correlated gene expression, and that the relationship is not driven by gross tissue types. The set of genes we identify is significantly enriched for certain types of ion channels and synapse-related genes. We validate results by showing that polymorphisms in this set significantly correlate with alterations of in-vivo resting-state functional connectivity in a group of 259 adolescents. We further validate results on another species by showing that our list of genes is significantly associated with neuronal connectivity in the mouse brain. These results provide convergent, multimodal evidence that resting-state functional networks emerge from the orchestrated activity of dozens of genes linked to ion channel activity and synaptic function. Functional brain networks are also known to be perturbed in a variety of neurological and neuropsychological disorders, including Alzheimer's and schizophrenia. Given this link between disease and networks, and the fact that many brain disorders have genetic contributions, it seems that functional brain networks may be an interesting endophenotype for clinical use. We discuss the translational potential of the imaging genomics techniques we developed.
Organizers: Moritz Grosse-Wentrup
Human diseases show considerable heterogeneity at the molecular level. Such heterogeneity is central to personalized medicine efforts that seek to exploit molecular data to better understand disease biology and inform clinical decision making. An emerging notion is that diseases and disease subgroups may differ not only at the level of mean molecular abundance, but also with respect to patterns of molecular interplay. I will discuss our ongoing efforts to develop methods to investigate such heterogeneity, with an emphasis on some high-dimensional aspects.