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Development and Evaluation of a Portable BCI System for Remote Data Acquisition

Emde, T.

Graduate School of Neural Information Processing, Eberhard Karls Universität Tübingen, Germany, 2017 (mastersthesis)

[BibTex]

[BibTex]


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Brain-Computer Interfaces for patients with Amyotrophic Lateral Sclerosis

Fomina, T.

Eberhard Karls Universität Tübingen, Germany, 2017 (phdthesis)

[BibTex]

[BibTex]


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Causal models for decision making via integrative inference

Geiger, P.

University of Stuttgart, Germany, 2017 (phdthesis)

[BibTex]

[BibTex]


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Learning Optimal Configurations for Modeling Frowning by Transcranial Electrical Stimulation

Sücker, K.

Graduate School of Neural Information Processing, Eberhard Karls Universität Tübingen, Germany, 2017 (mastersthesis)

[BibTex]

[BibTex]

2014


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Modeling the polygenic architecture of complex traits

Rakitsch, Barbara

Eberhard Karls Universität Tübingen, November 2014 (phdthesis)

[BibTex]

2014

[BibTex]


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Unsupervised identification of neural events in local field potentials

Besserve, M., Schölkopf, B., Logothetis, N. K.

44th Annual Meeting of the Society for Neuroscience (Neuroscience), 2014 (talk)

[BibTex]

[BibTex]


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A Novel Causal Inference Method for Time Series

Shajarisales, N.

Eberhard Karls Universität Tübingen, Germany, Eberhard Karls Universität Tübingen, Germany, 2014 (mastersthesis)

PDF [BibTex]

PDF [BibTex]


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Quantifying statistical dependency

Besserve, M.

Research Network on Learning Systems Summer School, 2014 (talk)

[BibTex]

[BibTex]


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A global analysis of extreme events and consequences for the terrestrial carbon cycle

Zscheischler, J.

Diss. No. 22043, ETH Zurich, Switzerland, ETH Zurich, Switzerland, 2014 (phdthesis)

[BibTex]

[BibTex]


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Development of advanced methods for improving astronomical images

Schmeißer, N.

Eberhard Karls Universität Tübingen, Germany, Eberhard Karls Universität Tübingen, Germany, 2014 (diplomathesis)

[BibTex]

[BibTex]


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The Feasibility of Causal Discovery in Complex Systems: An Examination of Climate Change Attribution and Detection

Lacosse, E.

Graduate Training Centre of Neuroscience, University of Tübingen, Germany, Graduate Training Centre of Neuroscience, University of Tübingen, Germany, 2014 (mastersthesis)

[BibTex]

[BibTex]


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Causal Discovery in the Presence of Time-Dependent Relations or Small Sample Size

Huang, B.

Graduate Training Centre of Neuroscience, University of Tübingen, Germany, Graduate Training Centre of Neuroscience, University of Tübingen, Germany, 2014 (mastersthesis)

[BibTex]

[BibTex]


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Analysis of Distance Functions in Graphs

Alamgir, M.

University of Hamburg, Germany, University of Hamburg, Germany, 2014 (phdthesis)

[BibTex]

[BibTex]

2012


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Support Vector Machines, Support Measure Machines, and Quasar Target Selection

Muandet, K.

Center for Cosmology and Particle Physics (CCPP), New York University, December 2012 (talk)

[BibTex]

2012

[BibTex]


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Hilbert Space Embedding for Dirichlet Process Mixtures

Muandet, K.

NIPS Workshop on Confluence between Kernel Methods and Graphical Models, December 2012 (talk)

[BibTex]

[BibTex]


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Scalable graph kernels

Shervashidze, N.

Eberhard Karls Universität Tübingen, Germany, October 2012 (phdthesis)

Web [BibTex]

Web [BibTex]


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Probabilistic Modelling of Expression Variation in Modern eQTL Studies

Zwießele, M.

Eberhard Karls Universität Tübingen, Germany, October 2012 (mastersthesis)

[BibTex]

[BibTex]


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Simultaneous small animal PET/MR in activated and resting state reveals multiple brain networks

Wehrl, H., Lankes, K., Hossain, M., Bezrukov, I., Liu, C., Martirosian, P., Schick, F., Pichler, B.

20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM), May 2012 (talk)

Web [BibTex]

Web [BibTex]


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A new PET insert for simultaneous PET/MR small animal imaging

Wehrl, H., Lankes, K., Hossain, M., Bezrukov, I., Liu, C., Martirosian, P., Reischl, G., Schick, F., Pichler, B.

20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM), May 2012 (talk)

Web [BibTex]

Web [BibTex]


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Evaluation of a new, large field of view, small animal PET/MR system

Hossain, M., Wehrl, H., Lankes, K., Liu, C., Bezrukov, I., Reischl, G., Pichler, B.

50. Jahrestagung der Deutschen Gesellschaft fuer Nuklearmedizin (NuklearMedizin), April 2012 (talk)

Web [BibTex]

Web [BibTex]


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Learning Motor Skills: From Algorithms to Robot Experiments

Kober, J.

Technische Universität Darmstadt, Germany, March 2012 (phdthesis)

PDF [BibTex]

PDF [BibTex]


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Support Measure Machines for Quasar Target Selection

Muandet, K.

Astro Imaging Workshop, 2012 (talk)

Abstract
In this talk I will discuss the problem of quasar target selection. The objects attributes in astronomy such as fluxes are often subjected to substantial and heterogeneous measurement uncertainties, especially for the medium-redshift between 2.2 and 3.5 quasars which is relatively rare and must be targeted down to g ~ 22 mag. Most of the previous works for quasar target selection includes UV-excess, kernel density estimation, a likelihood approach, and artificial neural network cannot directly deal with the heterogeneous input uncertainties. Recently, extreme deconvolution (XD) has been used to tackle this problem in a well-posed manner. In this work, we present a discriminative approach for quasar target selection that can deal with input uncertainties directly. To do so, we represent each object as a Gaussian distribution whose mean is the object's attribute vector and covariance is the given flux measurement uncertainty. Given a training set of Gaussian distributions, the support measure machines (SMMs) algorithm are trained and used to build the quasar targeting catalog. Preliminary results will also be presented. Joint work with Jo Bovy and Bernhard Sch{\"o}lkopf

Web [BibTex]


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PAC-Bayesian Analysis: A Link Between Inference and Statistical Physics

Seldin, Y.

Workshop on Statistical Physics of Inference and Control Theory, 2012 (talk)

Web [BibTex]

Web [BibTex]


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PET Performance Measurements of a Next Generation Dedicated Small Animal PET/MR Scanner

Liu, C., Hossain, M., Lankes, K., Bezrukov, I., Wehrl, H., Kolb, A., Judenhofer, M., Pichler, B.

Nuclear Science Symposium and Medical Imaging Conference (NSS-MIC), 2012 (talk)

[BibTex]

[BibTex]


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Structure and Dynamics of Diffusion Networks

Gomez Rodriguez, M.

Department of Electrical Engineering, Stanford University, 2012 (phdthesis)

Web [BibTex]

Web [BibTex]


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Simultaneous small animal PET/MR reveals different brain networks during stimulation and rest

Wehrl, H., Hossain, M., Lankes, K., Liu, C., Bezrukov, I., Martirosian, P., Reischl, G., Schick, F., Pichler, B.

World Molecular Imaging Congress (WMIC), 2012 (talk)

[BibTex]

[BibTex]


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Blind Deconvolution in Scientific Imaging & Computational Photography

Hirsch, M.

Eberhard Karls Universität Tübingen, Germany, 2012 (phdthesis)

Web [BibTex]

Web [BibTex]


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PAC-Bayesian Analysis of Supervised, Unsupervised, and Reinforcement Learning

Seldin, Y., Laviolette, F., Shawe-Taylor, J.

Tutorial at the 29th International Conference on Machine Learning (ICML), 2012 (talk)

Web Web [BibTex]

Web Web [BibTex]


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Influence of MR-based attenuation correction on lesions within bone and susceptibility artifact regions

Bezrukov, I., Schmidt, H., Mantlik, F., Schwenzer, N., Brendle, C., Pichler, B.

Molekulare Bildgebung (MoBi), 2012 (talk)

[BibTex]

[BibTex]


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Structured Apprenticeship Learning

Boularias, A., Kroemer, O., Peters, J.

European Workshop on Reinforcement Learning (EWRL), 2012 (talk)

[BibTex]

[BibTex]


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PAC-Bayesian Analysis and Its Applications

Seldin, Y., Laviolette, F., Shawe-Taylor, J.

Tutorial at The European Conference on Machine Learning and Principles and Practice of Knowledge Discovery in Databases (ECML-PKDD), 2012 (talk)

Web [BibTex]

Web [BibTex]


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Kernel Bellman Equations in POMDPs

Nishiyama, Y., Boularias, A., Gretton, A., Fukumizu, K.

Technical Committee on Infomation-Based Induction Sciences and Machine Learning (IBISML'12), 2012 (talk)

[BibTex]

[BibTex]


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Beta oscillations propagate as traveling waves in the macaque prefrontal cortex

Panagiotaropoulos, T., Besserve, M., Logothetis, N.

42nd Annual Meeting of the Society for Neuroscience (Neuroscience), 2012 (talk)

[BibTex]

[BibTex]


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Mining correlated loci at a genome-wide scale

Velkov, V.

Eberhard Karls Universität Tübingen, Germany, 2012 (mastersthesis)

[BibTex]

[BibTex]

2011


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Combined whole-body PET/MR imaging: MR contrast agents do not affect the quantitative accuracy of PET following attenuation correction

Lois, C., Kupferschläger, J., Bezrukov, I., Schmidt, H., Werner, M., Mannheim, J., Pichler, B., Schwenzer, N., Beyer, T.

(SST15-05 ), 97th Scientific Assemble and Annual Meeting of the Radiological Society of North America (RSNA), December 2011 (talk)

Abstract
PURPOSE Combined PET/MR imaging entails the use of MR contrast agents (MRCA) as part of integrated protocols. We assess additional attenuation of the PET emission signals in the presence of oral and intraveneous (iv) MRCA made up of iron oxide and Gd-chelates, respectively. METHOD AND MATERIALS Phantom scans were performed on a clinical PET/CT (Biograph HiRez16, Siemens) and integrated whole-body PET/MR (Biograph mMR, Siemens) using oral (Lumirem) and intraveneous (Gadovist) MRCA. Reference PET attenuation values were determined on a small-animal PET (Inveon, Siemens) using standard PET transmission imaging (TX). Seven syringes of 5mL were filled with (a) Water, (b) Lumirem_100 (100% conc.), (c) Gadovist_100 (100%), (d) Gadovist_18 (18%), (e) Gadovist_02 (0.2%), (f) Imeron-400 CT iv-contrast (100%) and (g) Imeron-400 (2.4%). The same set of syringes was scanned on CT (Sensation16, Siemens) at 120kVp and 160mAs. The effect of MRCA on the attenuation of PET emission data was evaluated using a 20cm cylinder filled uniformly with [18F]-FDG (FDG) in water (BGD). Three 4.5cm diameter cylinders were inserted into the phantom: (C1) Teflon, (C2) Water+FDG (2:1) and (C3) Lumirem_100+FDG (2:1). Two 50mL syringes filled with Gadovist_02+FDG (Sy1) and water+FDG (Sy2) were attached to the sides of (C1) to mimick the effects of iv-contrast in vessels near bone. Syringe-to-background activity ratio was 4-to-1. PET emission data were acquired for 10min each using the PET/CT and the PET/MR. Images were reconstructed using CT- and MR-based attenuation correction. RESULTS Mean linear PET attenuation (cm-1) on TX was (a) 0.098, (b) 0.098, (c) 0.300, (d) 0.134, (e) 0.095, (f) 0.397 and (g) 0.105. Corresponding CT attenuation (HU) was: (a) 5, (b) 14, (c) 3070, (d) 1040, (e) 13, (f) 3070 and (g) 347. Lumirem had little effect on PET attenuation with (C3) being 13% and 10% higher than (C2) on PET/CT and PET/MR, respectively. Gadovist_02 had even smaller effects with (Sy1) being 2.5% lower than (Sy2) on PET/CT and 1.2% higher than (Sy2) on PET/MR. CONCLUSION MRCA in high and clinically relevant concentrations have attenuation values similar to that of CT contrast and water, respectively. In clinical PET/MR scenarios MRCA are not expected to lead to significant attenuation of the PET emission signals.

Web [BibTex]

2011

Web [BibTex]


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Cooperative Cuts: a new use of submodularity in image segmentation

Jegelka, S.

Second I.S.T. Austria Symposium on Computer Vision and Machine Learning, October 2011 (talk)

Web [BibTex]

Web [BibTex]


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Effect of MR Contrast Agents on Quantitative Accuracy of PET in Combined Whole-Body PET/MR Imaging

Lois, C., Bezrukov, I., Schmidt, H., Schwenzer, N., Werner, M., Pichler, B., Kupferschläger, J., Beyer, T.

2011(MIC3-3), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (talk)

Abstract
Combined whole-body PET/MR systems are being tested in clinical practice today. Integrated imaging protocols entail the use of MR contrast agents (MRCA) that could bias PET attenuation correction. In this work, we assess the effect of MRCA in PET/MR imaging. We analyze the effect of oral and intravenous MRCA on PET activity after attenuation correction. We conclude that in clinical scenarios, MRCA are not expected to lead to significant attenuation of PET signals, and that attenuation maps are not biased after the ingestion of adequate oral contrasts.

Web [BibTex]

Web [BibTex]


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First Results on Patients and Phantoms of a Fully Integrated Clinical Whole-Body PET/MRI

Schmidt, H., Schwenzer, N., Bezrukov, I., Kolb, A., Mantlik, F., Kupferschläger, J., Lois, C., Sauter, A., Brendle, C., Pfannenberg, C., Pichler, B.

2011(J2-8), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (talk)

Abstract
First clinical fully integrated whole-body PET/MR scanners are just entering the field. Here, we present studies toward quantification accuracy and variation within the PET field of view of small lesions from our BrainPET/MRI, a dedicated clinical brain scanner which was installed three years ago in Tbingen. Also, we present first results for patient and phantom scans of a fully integral whole-body PET/MRI, which was installed two months ago at our department. The quantification accuracy and homogeneity of the BrainPET-Insert (Siemens Medical Solutions, Germany) installed inside the magnet bore of a clinical 3T MRI scanner (Magnetom TIM Trio, Siemens Medical Solutions, Germany) was evaluated by using eight hollow spheres with inner diameters from 3.95 to 7.86 mm placed at different positions inside a homogeneous cylinder phantom with an 9:1 and 6:1 sphere to background ratio. The quantification accuracy for small lesions at different positions in the PET FoV shows a standard deviation of up to 11% and is acceptable for quantitative brain studies where the homogeneity of quantification on the entire FoV is essental. Image quality and resolution of the new Siemens whole-body PET/MR system (Biograph mMR, Siemens Medical Solutions, Germany) was evaluated according to the NEMA NU2 2007 protocol using a body phantom containing six spheres with inner diameter from 10 to 37 mm at sphere to background ratios of 8:1 and 4:1 and the F-18 point sources located at different positions inside the PET FoV, respectively. The evaluation of the whole-body PET/MR system reveals a good PET image quality and resolution comparable to state-of-the-art clinical PET/CT scanners. First images of patient studies carried out at the whole-body PET/MR are presented highlighting the potency of combined PET/MR imaging.

Web [BibTex]

Web [BibTex]


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Effect of MR contrast agents on quantitative accuracy of PET in combined whole-body PET/MR imaging

Lois, C., Kupferschläger, J., Bezrukov, I., Schmidt, H., Werner, M., Mannheim, J., Pichler, B., Schwenzer, N., Beyer, T.

(OP314), Annual Congress of the European Association of Nuclear Medicine (EANM), October 2011 (talk)

Abstract
PURPOSE:Combined PET/MR imaging entails the use of MR contrast agents (MRCA) as part of integrated protocols. MRCA are made up of iron oxide and Gd-chelates for oral and intravenous (iv) application, respectively. We assess additional attenuation of the PET emission signals in the presence of oral and iv MRCA.MATERIALS AND METHODS:Phantom scans were performed on a clinical PET/CT (Biograph HiRez16, Siemens) and an integrated whole-body PET/MR (Biograph mMR, Siemens). Two common MRCA were evaluated: Lumirem (oral) and Gadovist (iv).Reference PET attenuation values were determined on a dedicated small-animal PET (Inveon, Siemens) using equivalent standard PET transmission source imaging (TX). Seven syringes of 5mL were filled with (a) Water, (b) Lumirem_100 (100% concentration), (c) Gadovist_100 (100%), (d) Gadovist_18 (18%), (e) Gadovist_02 (0.2%), (f) Imeron-400 CT iv-contrast (100%) and (g) Imeron-400 (2.4%). The same set of syringes was scanned on CT (Sensation16, Siemens) at 120kVp and 160mAs.The effect of MRCA on the attenuation of PET emission data was evaluated using a 20cm cylinder filled uniformly with [18F]-FDG (FDG) in water (BGD). Three 4.5cm diameter cylinders were inserted into the phantom: (C1) Teflon, (C2) Water+FDG (2:1) and (C3) Lumirem_100+FDG (2:1). Two 50mL syringes filled with Gadovist_02+FDG (Sy1) and water+FDG (Sy2) were attached to the sides of (C1) to mimick the effects of iv-contrast in vessels near bone. Syringe-to-background activity ratio was 4-to-1.PET emission data were acquired for 10min each using the PET/CT and the PET/MR. Images were reconstructed using CT- and MR-based attenuation correction (AC). Since Teflon is not correctly identified on MR, PET(/MR) data were reconstructed using MR-AC and CT-AC.RESULTS:Mean linear PET attenuation (cm-1) on TX was (a) 0.098, (b) 0.098, (c) 0.300, (d) 0.134, (e) 0.095, (f) 0.397 and (g) 0.105. Corresponding CT attenuation (HU) was: (a) 5, (b) 14, (c) 3070, (d) 1040, (e) 13, (f) 3070 and (g) 347.Lumirem had little effect on PET attenuation with (C3) being 13%, 10% and 11% higher than (C2) on PET/CT, PET/MR with MR-AC, and PET/MR with CT-AC, respectively. Gadovist_02 had even smaller effects with (Sy1) being 2.5% lower, 1.2% higher, and 3.5% lower than (Sy2) on PET/CT, PET/MR with MR-AC and PET/MR with CT-AC, respectively.CONCLUSION:MRCA in high and clinically relevant concentrations have attenuation values similar to that of CT contrast and water, respectively. In clinical PET/MR scenarios MRCA are not expected to lead to significant attenuation of the PET emission signals.

Web [BibTex]

Web [BibTex]