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2012


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Blind Retrospective Motion Correction of MR Images

Loktyushin, A., Nickisch, H., Pohmann, R., Schölkopf, B.

20th Annual Scientific Meeting ISMRM, May 2012 (poster)

Abstract
Patient motion in the scanner is one of the most challenging problems in MRI. We propose a new retrospective motion correction method for which no tracking devices or specialized sequences are required. We seek the motion parameters such that the image gradients in the spatial domain become sparse. We then use these parameters to invert the motion and recover the sharp image. In our experiments we acquired 2D TSE images and 3D FLASH/MPRAGE volumes of the human head. Major quality improvements are possible in the 2D case and substantial improvements in the 3D case.

Web [BibTex]

2012

Web [BibTex]


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Identifying endogenous rhythmic spatio-temporal patterns in micro-electrode array recordings

Besserve, M., Panagiotaropoulos, T., Crocker, B., Kapoor, V., Tolias, A., Panzeri, S., Logothetis, N.

9th annual Computational and Systems Neuroscience meeting (Cosyne), 2012 (poster)

[BibTex]

[BibTex]


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Reconstruction using Gaussian mixture models

Joubert, P., Habeck, M.

2012 Gordon Research Conference on Three-Dimensional Electron Microscopy (3DEM), 2012 (poster)

Web [BibTex]

Web [BibTex]


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Learning from Distributions via Support Measure Machines

Muandet, K., Fukumizu, K., Dinuzzo, F., Schölkopf, B.

26th Annual Conference on Neural Information Processing Systems (NIPS), 2012 (poster)

PDF [BibTex]

PDF [BibTex]


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Juggling Increases Interhemispheric Brain Connectivity: A Visual and Quantitative dMRI Study.

Schultz, T., Gerber, P., Schmidt-Wilcke, T.

Vision, Modeling and Visualization (VMV), 2012 (poster)

[BibTex]

[BibTex]


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The geometry and statistics of geometric trees

Feragen, A., Lo, P., de Bruijne, M., Nielsen, M., Lauze, F.

T{\"u}bIt day of bioinformatics, June, 2012 (poster)

[BibTex]

[BibTex]


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Therapy monitoring of patients with chronic sclerodermic graft-versus-host-disease using PET/MRI

Sauter, A., Schmidt, H., Mantlik, F., Kolb, A., Federmann, B., Bethge, W., Reimold, M., Pfannenberg, C., Pichler, B., Horger, M.

2012 SNM Annual Meeting, 2012 (poster)

Web [BibTex]

Web [BibTex]


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Centrality of the Mammalian Functional Brain Network

Besserve, M., Bartels, A., Murayama, Y., Logothetis, N.

42nd Annual Meeting of the Society for Neuroscience (Neuroscience), 2012 (poster)

[BibTex]

[BibTex]


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Kernel Mean Embeddings of POMDPs

Nishiyama, Y., Boularias, A., Gretton, A., Fukumizu, K.

21st Machine Learning Summer School , 2012 (poster)

[BibTex]

[BibTex]


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Semi-Supervised Domain Adaptation with Copulas

Lopez-Paz, D., Hernandez-Lobato, J., Schölkopf, B.

Neural Information Processing Systems (NIPS), 2012 (poster)

PDF [BibTex]

PDF [BibTex]


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Evaluation of Whole-Body MR-Based Attenuation Correction in Bone and Soft Tissue Lesions

Bezrukov, I., Mantlik, F., Schmidt, H., Schwenzer, N., Brendle, C., Schölkopf, B., Pichler, B.

Nuclear Science Symposium and Medical Imaging Conference (NSS-MIC), 2012 (poster)

[BibTex]

[BibTex]


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The PET Performance Measurements of A Next Generation Dedicated Small Animal PET/MR Scanner

Liu, C., Hossain, M., Bezrukov, I., Wehrl, H., Kolb, A., Judenhofer, M., Pichler, B.

World Molecular Imaging Congress (WMIC), 2012 (poster)

[BibTex]

[BibTex]

2011


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Spatiotemporal mapping of rhythmic activity in the inferior convexity of the macaque prefrontal cortex

Panagiotaropoulos, T., Besserve, M., Crocker, B., Kapoor, V., Tolias, A., Panzeri, S., Logothetis, N.

41(239.15), 41st Annual Meeting of the Society for Neuroscience (Neuroscience), November 2011 (poster)

Abstract
The inferior convexity of the macaque prefrontal cortex (icPFC) is known to be involved in higher order processing of sensory information mediating stimulus selection, attention and working memory. Until now, the vast majority of electrophysiological investigations of the icPFC employed single electrode recordings. As a result, relatively little is known about the spatiotemporal structure of neuronal activity in this cortical area. Here we study in detail the spatiotemporal properties of local field potentials (LFP's) in the icPFC using multi electrode recordings during anesthesia. We computed the LFP-LFP coherence as a function of frequency for thousands of pairs of simultaneously recorded sites anterior to the arcuate and inferior to the principal sulcus. We observed two distinct peaks of coherent oscillatory activity between approximately 4-10 and 15-25 Hz. We then quantified the instantaneous phase of these frequency bands using the Hilbert transform and found robust phase gradients across recording sites. The dependency of the phase on the spatial location reflects the existence of traveling waves of electrical activity in the icPFC. The dominant axis of these traveling waves roughly followed the ventral-dorsal plane. Preliminary results show that repeated visual stimulation with a 10s movie had no dramatic effect on the spatial structure of the traveling waves. Traveling waves of electrical activity in the icPFC could reflect highly organized cortical processing in this area of prefrontal cortex.

Web [BibTex]

2011

Web [BibTex]


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Evaluation and Optimization of MR-Based Attenuation Correction Methods in Combined Brain PET/MR

Mantlik, F., Hofmann, M., Bezrukov, I., Schmidt, H., Kolb, A., Beyer, T., Reimold, M., Schölkopf, B., Pichler, B.

2011(MIC18.M-96), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (poster)

Abstract
Combined PET/MR provides simultaneous molecular and functional information in an anatomical context with unique soft tissue contrast. However, PET/MR does not support direct derivation of attenuation maps of objects and tissues within the measured PET field-of-view. Valid attenuation maps are required for quantitative PET imaging, specifically for scientific brain studies. Therefore, several methods have been proposed for MR-based attenuation correction (MR-AC). Last year, we performed an evaluation of different MR-AC methods, including simple MR thresholding, atlas- and machine learning-based MR-AC. CT-based AC served as gold standard reference. RoIs from 2 anatomic brain atlases with different levels of detail were used for evaluation of correction accuracy. We now extend our evaluation of different MR-AC methods by using an enlarged dataset of 23 patients from the integrated BrainPET/MR (Siemens Healthcare). Further, we analyze options for improving the MR-AC performance in terms of speed and accuracy. Finally, we assess the impact of ignoring BrainPET positioning aids during the course of MR-AC. This extended study confirms the overall prediction accuracy evaluation results of the first evaluation in a larger patient population. Removing datasets affected by metal artifacts from the Atlas-Patch database helped to improve prediction accuracy, although the size of the database was reduced by one half. Significant improvement in prediction speed can be gained at a cost of only slightly reduced accuracy, while further optimizations are still possible.

Web [BibTex]

Web [BibTex]


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Atlas- and Pattern Recognition Based Attenuation Correction on Simultaneous Whole-Body PET/MR

Bezrukov, I., Schmidt, H., Mantlik, F., Schwenzer, N., Hofmann, M., Schölkopf, B., Pichler, B.

2011(MIC18.M-116), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (poster)

Abstract
With the recent availability of clinical whole-body PET/MRI it is possible to evaluate and further develop MR-based attenuation correction methods using simultaneously acquired PET/MR data. We present first results for MRAC on patient data acquired on a fully integrated whole-body PET/MRI (Biograph mMR, Siemens) using our method that applies atlas registration and pattern recognition (ATPR) and compare them to the segmentation-based (SEG) method provided by the manufacturer. The ATPR method makes use of a database of previously aligned pairs of MR-CT volumes to predict attenuation values on a continuous scale. The robustness of the method in presence of MR artifacts was improved by location and size based detection. Lesion to liver and lesion to blood ratios (LLR and LBR) were compared for both methods on 29 iso-contour ROIs in 4 patients. ATPR showed >20% higher LBR and LLR for ROIs in and >7% near osseous tissue. For ROIs in soft tissue, both methods yielded similar ratios with max. differences <6% . For ROIs located within metal artifacts in the MR image, ATPR showed >190% higher LLR and LBR than SEG, where ratios <0.1 occured. For lesions in the neighborhood of artifacts, both ratios were >15% higher for ATPR. If artifacts in MR volumes caused by metal implants are not accounted for in the computation of attenuation maps, they can lead to a strong decrease of lesion to background ratios, even to disappearance of hot spots. Metal implants are likely to occur in the patient collective receiving combined PET/MR scans, of our first 10 patients, 3 had metal implants. Our method is currently able to account for artifacts in the pelvis caused by prostheses. The ability of the ATPR method to account for bone leads to a significant increase of LLR and LBR in osseous tissue, which supports our previous evaluations with combined PET/CT and PET/MR data. For lesions within soft tissue, lesion to background ratios of ATPR and SEG were comparable.

Web [BibTex]

Web [BibTex]


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Retrospective blind motion correction of MR images

Loktyushin, A., Nickisch, H., Pohmann, R.

Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):498, 28th Annual Scientific Meeting ESMRMB, October 2011 (poster)

Abstract
We present a retrospective method, which significantly reduces ghosting and blurring artifacts due to subject motion. No modifications to the sequence (as in [2, 3]), or the use of additional equipment (as in [1]) are required. Our method iteratively searches for the transformation, that applied to the lines in k-space -- yields the sparsest Laplacian filter output in the spatial domain.

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


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Model based reconstruction for GRE EPI

Blecher, W., Pohmann, R., Schölkopf, B., Seeger, M.

Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):493-494, 28th Annual Scientific Meeting ESMRMB, October 2011 (poster)

Abstract
Model based nonlinear image reconstruction methods for MRI [3] are at the heart of modern reconstruction techniques (e.g.compressed sensing [6]). In general, models are expressed as a matrix equation where y and u are column vectors of k-space and image data, X model matrix and e independent noise. However, solving the corresponding linear system is not tractable. Therefore fast nonlinear algorithms that minimize a function wrt.the unknown image are the method of choice: In this work a model for gradient echo EPI, is proposed that incorporates N/2 Ghost correction and correction for field inhomogeneities. In addition to reconstruction from full data, the model allows for sparse reconstruction, joint estimation of image, field-, and relaxation-map (like [5,8] for spiral imaging), and improved N/2 ghost correction.

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


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Simultaneous multimodal imaging of patients with bronchial carcinoma in a whole body MR/PET system

Brendle, C., Sauter, A., Schmidt, H., Schraml, C., Bezrukov, I., Martirosian, P., Hetzel, J., Müller, M., Claussen, C., Schwenzer, N., Pfannenberg, C.

Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):141, 28th annual scientific meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRB), October 2011 (poster)

Abstract
Purpose/Introduction: Lung cancer is among the most frequent cancers (1). Exact determination of tumour extent and viability is crucial for adequate therapy guidance. [18F]-FDG-PET allows accurate staging and the evaluation of therapy response based on glucose metabolism. Diffusion weighted MRI (DWI) is another promising tool for the evaluation of tumour viability (2,3). The aim of the study was the simultaneous PET-MR acquisition in lung cancer patients and correlation of PET and MR data. Subjects and Methods: Seven patients (age 38-73 years, mean 61 years) with highly suspected or known bronchial carcinoma were examined. First, a [18F]-FDG-PET/CT was performed (injected dose: 332-380 MBq). Subsequently, patients were examined at the whole-body MR/PET (Siemens Biograph mMR). The MRI is a modified 3T Verio whole body system with a magnet bore of 60 cm (max. amplitude gradients 45 mT/m, max. slew rate 200 T/m/s). Concerning the PET, the whole-body MR/PET system comprises 56 detector cassettes with a 59.4 cm transaxial and 25.8 cm axial FoV. The following parameters for PET acquisition were applied: 2 bed positions, 6 min/bed with an average uptake time of 124 min after injection (range: 110-143 min). The attenuation correction of PET data was conducted with a segmentation-based method provided by the manufacturer. Acquired PET data were reconstructed with an iterative 3D OSEM algorithm using 3 iterations and 21 subsets, Gaussian filter of 3 mm. DWI MR images were recorded simultaneously for each bed using two b-values (0/800 s/mm2). SUVmax and ADCmin were assessed in a ROI analysis. The following ratios were calculated: SUVmax(tumor)/SUVmean(liver) and ADCmin(tumor)/ADCmean(muscle). Correlation between SUV and ADC was analyzed (Pearson’s correlation). Results: Diagnostic scans could be obtained in all patients with good tumour delineation. The spatial matching of PET and DWI data was very exact. Most tumours showed a pronounced FDG-uptake in combination with decreased ADC values. Significant correlation was found between SUV and ADC ratios (r = -0.87, p = 0.0118). Discussion/Conclusion: Simultaneous MR/PET imaging of lung cancer is feasible. The whole-body MR/PET system can provide complementary information regarding tumour viability and cellularity which could facilitate a more profound tumour characterization. Further studies have to be done to evaluate the importance of these parameters for therapy decisions and monitoring

Web DOI [BibTex]

Web DOI [BibTex]


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Support Vector Machines for finding deletions and short insertions using paired-end short reads

Grimm, D., Hagmann, J., König, D., Weigel, D., Borgwardt, KM.

International Conference on Intelligent Systems for Molecular Biology (ISMB), 2011 (poster)

Web [BibTex]

Web [BibTex]


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Statistical estimation for optimization problems on graphs

Langovoy, M., Sra, S.

Empirical Inference Symposium, 2011 (poster)

[BibTex]


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Transfer Learning with Copulas

Lopez-Paz, D., Hernandez-Lobato, J.

Neural Information Processing Systems (NIPS), 2011 (poster)

PDF [BibTex]

PDF [BibTex]

2000


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Contrast discrimination using periodic pulse trains

Wichmann, F., Henning, G.

pages: 74, 3. T{\"u}binger Wahrnehmungskonferenz (TWK), February 2000 (poster)

Abstract
Understanding contrast transduction is essential for understanding spatial vision. Previous research (Wichmann et al. 1998; Wichmann, 1999; Henning and Wichmann, 1999) has demonstrated the importance of high contrasts to distinguish between alternative models of contrast discrimination. However, the modulation transfer function of the eye imposes large contrast losses on stimuli, particularly for stimuli of high spatial frequency, making high retinal contrasts difficult to obtain using sinusoidal gratings. Standard 2AFC contrast discrimination experiments were conducted using periodic pulse trains as stimuli. Given our Mitsubishi display we achieve stimuli with up to 160% contrast at the fundamental frequency. The shape of the threshold versus (pedestal) contrast (TvC) curve using pulse trains shows the characteristic dipper shape, i.e. contrast discrimination is sometimes “easier” than detection. The rising part of the TvC function has the same slope as that measured for contrast discrimination using sinusoidal gratings of the same frequency as the fundamental. Periodic pulse trains offer the possibility to explore the visual system’s properties using high retinal contrasts. Thus they might prove useful in tasks other than contrast discrimination. Second, at least for high spatial frequencies (8 c/deg) it appears that contrast discrimination using sinusoids and periodic pulse trains results in virtually identical TvC functions, indicating a lack of probability summation. Further implications of these results are discussed.

Web [BibTex]

2000

Web [BibTex]


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Subliminale Darbietung verkehrsrelevanter Information in Kraftfahrzeugen

Staedtgen, M., Hahn, S., Franz, MO., Spitzer, M.

pages: 98, (Editors: H.H. Bülthoff, K.R. Gegenfurtner, H.A. Mallot), 3. T{\"u}binger Wahrnehmungskonferenz (TWK), February 2000 (poster)

Abstract
Durch moderne Bildverarbeitungstechnologien ist es m{\"o}glich, in Kraftfahrzeugen bestimmte kritische Verkehrssituationen automatisch zu erkennen und den Fahrer zu warnen bzw. zu informieren. Ein Problem ist dabei die Darbietung der Ergebnisse, die den Fahrer m{\"o}glichst wenig belasten und seine Aufmerksamkeit nicht durch zus{\"a}tzliche Warnleuchten oder akustische Signale vom Verkehrsgeschehen ablenken soll. In einer Reihe von Experimenten wurde deshalb untersucht, ob subliminal dargebotene, das heißt nicht bewußt wahrgenommene, verkehrsrelevante Informationen verhaltenswirksam werden und zur Informations{\"u}bermittlung an den Fahrer genutzt werden k{\"o}nnen. In einem Experiment zur semantischen Bahnung konnte mit Hilfe einer lexikalischen Entscheidungsaufgabe gezeigt werden, daß auf den Straßenverkehr bezogene Worte schneller verarbeitet werden, wenn vorher ein damit in Zusammenhang stehendes Bild eines Verkehrsschildes subliminal pr{\"a}sentiert wurde. Auch bei parafovealer Darbietung der subliminalen Stimuli wurde eine Beschleunigung erzielt. In einer visuellen Suchaufgabe wurden in Bildern realer Verkehrssituationen Verkehrszeichen schneller entdeckt, wenn das Bild des Verkehrszeichens vorher subliminal dargeboten wurde. In beiden Experimenten betrug die Pr{\"a}sentationszeit f{\"u}r die Hinweisreize 17 ms, zus{\"a}tzlich wurde durch Vorw{\"a}rts- und R{\"u}ckw{\"a}rtsmaskierung die bewußteWahrnehmung verhindert. Diese Laboruntersuchungen zeigten, daß sich auch im Kontext des Straßenverkehrs Beschleunigungen der Informationsverarbeitung durch subliminal dargebotene Stimuli erreichen lassen. In einem dritten Experiment wurde die Darbietung eines subliminalen Hinweisreizes auf die Reaktionszeit beim Bremsen in einem realen Fahrversuch untersucht. Die Versuchspersonen (n=17) sollten so schnell wie m{\"o}glich bremsen, wenn die Bremsleuchten eines im Abstand von 12-15 m voran fahrenden Fahrzeuges aufleuchteten. In 50 von insgesamt 100 Durchg{\"a}ngen wurde ein subliminaler Stimulus (zwei rote Punkte mit einem Zentimeter Durchmesser und zehn Zentimeter Abstand) 150 ms vor Aufleuchten der Bremslichter pr{\"a}sentiert. Die Darbietung erfolgte durch ein im Auto an Stelle des Tachometers integriertes TFT-LCD Display. Im Vergleich zur Reaktion ohne subliminalen Stimulus verk{\"u}rzte sich die Reaktionszeit dadurch signifikant um 51 ms. In den beschriebenen Experimenten konnte gezeigt werden, daß die subliminale Darbietung verkehrsrelevanter Information auch in Kraftfahrzeugen verhaltenswirksam werden kann. In Zukunft k{\"o}nnte durch die Kombination der online-Bildverarbeitung im Kraftfahrzeug mit subliminaler Darbietung der Ergebnisse eine Erh{\"o}hung der Verkehrssicherheit und des Komforts erreicht werden.

Web [BibTex]

Web [BibTex]