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2012


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Support Vector Machines, Support Measure Machines, and Quasar Target Selection

Muandet, K.

Center for Cosmology and Particle Physics (CCPP), New York University, December 2012 (talk)

[BibTex]

2012

[BibTex]


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Hilbert Space Embedding for Dirichlet Process Mixtures

Muandet, K.

NIPS Workshop on Confluence between Kernel Methods and Graphical Models, December 2012 (talk)

[BibTex]

[BibTex]


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Simultaneous small animal PET/MR in activated and resting state reveals multiple brain networks

Wehrl, H., Lankes, K., Hossain, M., Bezrukov, I., Liu, C., Martirosian, P., Schick, F., Pichler, B.

20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM), May 2012 (talk)

Web [BibTex]

Web [BibTex]


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A new PET insert for simultaneous PET/MR small animal imaging

Wehrl, H., Lankes, K., Hossain, M., Bezrukov, I., Liu, C., Martirosian, P., Reischl, G., Schick, F., Pichler, B.

20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM), May 2012 (talk)

Web [BibTex]

Web [BibTex]


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Evaluation of a new, large field of view, small animal PET/MR system

Hossain, M., Wehrl, H., Lankes, K., Liu, C., Bezrukov, I., Reischl, G., Pichler, B.

50. Jahrestagung der Deutschen Gesellschaft fuer Nuklearmedizin (NuklearMedizin), April 2012 (talk)

Web [BibTex]

Web [BibTex]


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Expectation-Maximization methods for solving (PO)MDPs and optimal control problems

Toussaint, M., Storkey, A., Harmeling, S.

In Inference and Learning in Dynamic Models, (Editors: Barber, D., Cemgil, A.T. and Chiappa, S.), Cambridge University Press, Cambridge, UK, January 2012 (inbook) In press

PDF [BibTex]

PDF [BibTex]


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Active Learning Methods in Classification of Remote Sensing Images

Bruzzone, L., Persello, C., Demir, B.

In Signal and Image Processing for Remote Sensing, (Editors: CH Chen), CRC Press, Boca Raton, FL, USA, January 2012 (inbook) In press

[BibTex]

[BibTex]


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Simultaneous small animal PET/MR reveals different brain networks during stimulation and rest

Wehrl, H., Hossain, M., Lankes, K., Liu, C., Bezrukov, I., Martirosian, P., Reischl, G., Schick, F., Pichler, B.

World Molecular Imaging Congress (WMIC), 2012 (talk)

[BibTex]

[BibTex]


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Support Measure Machines for Quasar Target Selection

Muandet, K.

Astro Imaging Workshop, 2012 (talk)

Abstract
In this talk I will discuss the problem of quasar target selection. The objects attributes in astronomy such as fluxes are often subjected to substantial and heterogeneous measurement uncertainties, especially for the medium-redshift between 2.2 and 3.5 quasars which is relatively rare and must be targeted down to g ~ 22 mag. Most of the previous works for quasar target selection includes UV-excess, kernel density estimation, a likelihood approach, and artificial neural network cannot directly deal with the heterogeneous input uncertainties. Recently, extreme deconvolution (XD) has been used to tackle this problem in a well-posed manner. In this work, we present a discriminative approach for quasar target selection that can deal with input uncertainties directly. To do so, we represent each object as a Gaussian distribution whose mean is the object's attribute vector and covariance is the given flux measurement uncertainty. Given a training set of Gaussian distributions, the support measure machines (SMMs) algorithm are trained and used to build the quasar targeting catalog. Preliminary results will also be presented. Joint work with Jo Bovy and Bernhard Sch{\"o}lkopf

Web [BibTex]


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PAC-Bayesian Analysis: A Link Between Inference and Statistical Physics

Seldin, Y.

Workshop on Statistical Physics of Inference and Control Theory, 2012 (talk)

Web [BibTex]

Web [BibTex]


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PET Performance Measurements of a Next Generation Dedicated Small Animal PET/MR Scanner

Liu, C., Hossain, M., Lankes, K., Bezrukov, I., Wehrl, H., Kolb, A., Judenhofer, M., Pichler, B.

Nuclear Science Symposium and Medical Imaging Conference (NSS-MIC), 2012 (talk)

[BibTex]

[BibTex]


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Inferential structure determination from NMR data

Habeck, M.

In Bayesian methods in structural bioinformatics, pages: 287-312, (Editors: Hamelryck, T., Mardia, K. V. and Ferkinghoff-Borg, J.), Springer, New York, 2012 (inbook)

[BibTex]

[BibTex]


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Robot Learning

Sigaud, O., Peters, J.

In Encyclopedia of the sciences of learning, (Editors: Seel, N.M.), Springer, Berlin, Germany, 2012 (inbook)

Web [BibTex]

Web [BibTex]


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Reinforcement Learning in Robotics: A Survey

Kober, J., Peters, J.

In Reinforcement Learning, 12, pages: 579-610, (Editors: Wiering, M. and Otterlo, M.), Springer, Berlin, Germany, 2012 (inbook)

Abstract
As most action generation problems of autonomous robots can be phrased in terms of sequential decision problems, robotics offers a tremendously important and interesting application platform for reinforcement learning. Similarly, the real-world challenges of this domain pose a major real-world check for reinforcement learning. Hence, the interplay between both disciplines can be seen as promising as the one between physics and mathematics. Nevertheless, only a fraction of the scientists working on reinforcement learning are sufficiently tied to robotics to oversee most problems encountered in this context. Thus, we will bring the most important challenges faced by robot reinforcement learning to their attention. To achieve this goal, we will attempt to survey most work that has successfully applied reinforcement learning to behavior generation for real robots. We discuss how the presented successful approaches have been made tractable despite the complexity of the domain and will study how representations or the inclusion of prior knowledge can make a significant difference. As a result, a particular focus of our chapter lies on the choice between model-based and model-free as well as between value function-based and policy search methods. As a result, we obtain a fairly complete survey of robot reinforcement learning which should allow a general reinforcement learning researcher to understand this domain.

Web DOI [BibTex]

Web DOI [BibTex]


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PAC-Bayesian Analysis of Supervised, Unsupervised, and Reinforcement Learning

Seldin, Y., Laviolette, F., Shawe-Taylor, J.

Tutorial at the 29th International Conference on Machine Learning (ICML), 2012 (talk)

Web Web [BibTex]

Web Web [BibTex]


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Influence of MR-based attenuation correction on lesions within bone and susceptibility artifact regions

Bezrukov, I., Schmidt, H., Mantlik, F., Schwenzer, N., Brendle, C., Pichler, B.

Molekulare Bildgebung (MoBi), 2012 (talk)

[BibTex]

[BibTex]


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Structured Apprenticeship Learning

Boularias, A., Kroemer, O., Peters, J.

European Workshop on Reinforcement Learning (EWRL), 2012 (talk)

[BibTex]

[BibTex]


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PAC-Bayesian Analysis and Its Applications

Seldin, Y., Laviolette, F., Shawe-Taylor, J.

Tutorial at The European Conference on Machine Learning and Principles and Practice of Knowledge Discovery in Databases (ECML-PKDD), 2012 (talk)

Web [BibTex]

Web [BibTex]


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Kernel Bellman Equations in POMDPs

Nishiyama, Y., Boularias, A., Gretton, A., Fukumizu, K.

Technical Committee on Infomation-Based Induction Sciences and Machine Learning (IBISML'12), 2012 (talk)

[BibTex]

[BibTex]


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Higher-Order Tensors in Diffusion MRI

Schultz, T., Fuster, A., Ghosh, A., Deriche, R., Florack, L., Lim, L.

In Visualization and Processing of Tensors and Higher Order Descriptors for Multi-Valued Data, (Editors: Westin, C. F., Vilanova, A. and Burgeth, B.), Springer, 2012 (inbook) Accepted

[BibTex]

[BibTex]


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Beta oscillations propagate as traveling waves in the macaque prefrontal cortex

Panagiotaropoulos, T., Besserve, M., Logothetis, N.

42nd Annual Meeting of the Society for Neuroscience (Neuroscience), 2012 (talk)

[BibTex]

[BibTex]

2009


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Machine Learning for Brain-Computer Interfaces

Hill, NJ.

Mini-Symposia on Assistive Machine Learning for People with Disabilities at NIPS (AMD), December 2009 (talk)

Abstract
Brain-computer interfaces (BCI) aim to be the ultimate in assistive technology: decoding a user‘s intentions directly from brain signals without involving any muscles or peripheral nerves. Thus, some classes of BCI potentially offer hope for users with even the most extreme cases of paralysis, such as in late-stage Amyotrophic Lateral Sclerosis, where nothing else currently allows communication of any kind. Other lines in BCI research aim to restore lost motor function in as natural a way as possible, reconnecting and in some cases re-training motor-cortical areas to control prosthetic, or previously paretic, limbs. Research and development are progressing on both invasive and non-invasive fronts, although BCI has yet to make a breakthrough to widespread clinical application. The high-noise high-dimensional nature of brain-signals, particularly in non-invasive approaches and in patient populations, make robust decoding techniques a necessity. Generally, the approach has been to use relatively simple feature extraction techniques, such as template matching and band-power estimation, coupled to simple linear classifiers. This has led to a prevailing view among applied BCI researchers that (sophisticated) machine-learning is irrelevant since "it doesn‘t matter what classifier you use once you‘ve done your preprocessing right and extracted the right features." I shall show a few examples of how this runs counter to both the empirical reality and the spirit of what needs to be done to bring BCI into clinical application. Along the way I‘ll highlight some of the interesting problems that remain open for machine-learners.

PDF Web Web [BibTex]

2009

PDF Web Web [BibTex]


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PAC-Bayesian Approach to Formulation of Clustering Objectives

Seldin, Y.

NIPS Workshop on "Clustering: Science or Art? Towards Principled Approaches", December 2009 (talk)

Abstract
Clustering is a widely used tool for exploratory data analysis. However, the theoretical understanding of clustering is very limited. We still do not have a well-founded answer to the seemingly simple question of "how many clusters are present in the data?", and furthermore a formal comparison of clusterings based on different optimization objectives is far beyond our abilities. The lack of good theoretical support gives rise to multiple heuristics that confuse the practitioners and stall development of the field. We suggest that the ill-posed nature of clustering problems is caused by the fact that clustering is often taken out of its subsequent application context. We argue that one does not cluster the data just for the sake of clustering it, but rather to facilitate the solution of some higher level task. By evaluation of the clustering‘s contribution to the solution of the higher level task it is possible to compare different clusterings, even those obtained by different optimization objectives. In the preceding work it was shown that such an approach can be applied to evaluation and design of co-clustering solutions. Here we suggest that this approach can be extended to other settings, where clustering is applied.

PDF Web Web [BibTex]

PDF Web Web [BibTex]


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Semi-supervised Kernel Canonical Correlation Analysis of Human Functional Magnetic Resonance Imaging Data

Shelton, JA.

Women in Machine Learning Workshop (WiML), December 2009 (talk)

Abstract
Kernel Canonical Correlation Analysis (KCCA) is a general technique for subspace learning that incorporates principal components analysis (PCA) and Fisher linear discriminant analysis (LDA) as special cases. By finding directions that maximize correlation, KCCA learns representations tied more closely to underlying process generating the the data and can ignore high-variance noise directions. However, for data where acquisition in a given modality is expensive or otherwise limited, KCCA may suffer from small sample effects. We propose to use semi-supervised Laplacian regularization to utilize data that are present in only one modality. This manifold learning approach is able to find highly correlated directions that also lie along the data manifold, resulting in a more robust estimate of correlated subspaces. Functional magnetic resonance imaging (fMRI) acquired data are naturally amenable to subspace techniques as data are well aligned and such data of the human brain are a particularly interesting candidate. In this study we implemented various supervised and semi-supervised versions of KCCA on human fMRI data, with regression to single and multivariate labels (corresponding to video content subjects viewed during the image acquisition). In each variate condition, Laplacian regularization improved performance whereas the semi-supervised variants of KCCA yielded the best performance. We additionally analyze the weights learned by the regression in order to infer brain regions that are important during different types of visual processing.

PDF Web [BibTex]


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Event-Related Potentials in Brain-Computer Interfacing

Hill, NJ.

Invited lecture on the bachelor & masters course "Introduction to Brain-Computer Interfacing", October 2009 (talk)

Abstract
An introduction to event-related potentials with specific reference to their use in brain-computer interfacing applications and research.

PDF [BibTex]

PDF [BibTex]


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BCI2000 and Python

Hill, NJ.

Invited lecture at the 5th International BCI2000 Workshop, October 2009 (talk)

Abstract
A tutorial, with exercises, on how to integrate your own Python code with the BCI2000 software package.

PDF [BibTex]

PDF [BibTex]


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Implementing a Signal Processing Filter in BCI2000 Using C++

Hill, NJ., Mellinger, J.

Invited lecture at the 5th International BCI2000 Workshop, October 2009 (talk)

Abstract
This tutorial shows how the functionality of the BCI2000 software package can be extended with one‘s own code, using BCI2000‘s C++ API.

PDF [BibTex]

PDF [BibTex]


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Toward a Theory of Consciousness

Tononi, G., Balduzzi, D.

In The Cognitive Neurosciences, pages: 1201-1220, (Editors: Gazzaniga, M.S.), MIT Press, Cambridge, MA, USA, October 2009 (inbook)

Web [BibTex]

Web [BibTex]


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Randomized algorithms for statistical image analysis based on percolation theory

Davies, P., Langovoy, M., Wittich, O.

27th European Meeting of Statisticians (EMS), July 2009 (talk)

Abstract
We propose a novel probabilistic method for detection of signals and reconstruction of images in the presence of random noise. The method uses results from percolation and random graph theories (see Grimmett (1999)). We address the problem of detection and estimation of signals in situations where the signal-to-noise ratio is particularly low. We present an algorithm that allows to detect objects of various shapes in noisy images. The algorithm has linear complexity and exponential accuracy. Our algorithm substantially di ers from wavelets-based algorithms (see Arias-Castro et.al. (2005)). Moreover, we present an algorithm that produces a crude estimate of an object based on the noisy picture. This algorithm also has linear complexity and is appropriate for real-time systems. We prove results on consistency and algorithmic complexity of our procedures.

Web PDF [BibTex]

Web PDF [BibTex]


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Learning Motor Primitives for Robotics

Kober, J., Peters, J., Oztop, E.

Advanced Telecommunications Research Center ATR, June 2009 (talk)

Abstract
The acquisition and self-improvement of novel motor skills is among the most important problems in robotics. Motor primitives offer one of the most promising frameworks for the application of machine learning techniques in this context. Employing the Dynamic Systems Motor primitives originally introduced by Ijspeert et al. (2003), appropriate learning algorithms for a concerted approach of both imitation and reinforcement learning are presented. Using these algorithms new motor skills, i.e., Ball-in-a-Cup, Ball-Paddling and Dart-Throwing, are learned.

[BibTex]

[BibTex]


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Text Clustering with Mixture of von Mises-Fisher Distributions

Sra, S., Banerjee, A., Ghosh, J., Dhillon, I.

In Text mining: classification, clustering, and applications, pages: 121-161, Chapman & Hall/CRC data mining and knowledge discovery series, (Editors: Srivastava, A. N. and Sahami, M.), CRC Press, Boca Raton, FL, USA, June 2009 (inbook)

Web DOI [BibTex]

Web DOI [BibTex]


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Learning To Detect Unseen Object Classes by Between-Class Attribute Transfer

Lampert, C.

IEEE Computer Society Conference on Computer Vision and Pattern Recognition (CVPR), June 2009 (talk)

Web [BibTex]

Web [BibTex]


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Data Mining for Biologists

Tsuda, K.

In Biological Data Mining in Protein Interaction Networks, pages: 14-27, (Editors: Li, X. and Ng, S.-K.), Medical Information Science Reference, Hershey, PA, USA, May 2009 (inbook)

Abstract
In this tutorial chapter, we review basics about frequent pattern mining algorithms, including itemset mining, association rule mining and graph mining. These algorithms can find frequently appearing substructures in discrete data. They can discover structural motifs, for example, from mutation data, protein structures and chemical compounds. As they have been primarily used for business data, biological applications are not so common yet, but their potential impact would be large. Recent advances in computers including multicore machines and ever increasing memory capacity support the application of such methods to larger datasets. We explain technical aspects of the algorithms, but do not go into details. Current biological applications are summarized and possible future directions are given.

Web [BibTex]

Web [BibTex]


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Large Margin Methods for Part of Speech Tagging

Altun, Y.

In Automatic Speech and Speaker Recognition: Large Margin and Kernel Methods, pages: 141-160, (Editors: Keshet, J. and Bengio, S.), Wiley, Hoboken, NJ, USA, January 2009 (inbook)

Web [BibTex]

Web [BibTex]


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Covariate shift and local learning by distribution matching

Gretton, A., Smola, A., Huang, J., Schmittfull, M., Borgwardt, K., Schölkopf, B.

In Dataset Shift in Machine Learning, pages: 131-160, (Editors: Quiñonero-Candela, J., Sugiyama, M., Schwaighofer, A. and Lawrence, N. D.), MIT Press, Cambridge, MA, USA, 2009 (inbook)

Abstract
Given sets of observations of training and test data, we consider the problem of re-weighting the training data such that its distribution more closely matches that of the test data. We achieve this goal by matching covariate distributions between training and test sets in a high dimensional feature space (specifically, a reproducing kernel Hilbert space). This approach does not require distribution estimation. Instead, the sample weights are obtained by a simple quadratic programming procedure. We provide a uniform convergence bound on the distance between the reweighted training feature mean and the test feature mean, a transductive bound on the expected loss of an algorithm trained on the reweighted data, and a connection to single class SVMs. While our method is designed to deal with the case of simple covariate shift (in the sense of Chapter ??), we have also found benefits for sample selection bias on the labels. Our correction procedure yields its greatest and most consistent advantages when the learning algorithm returns a classifier/regressor that is simpler" than the data might suggest.

PDF Web [BibTex]

PDF Web [BibTex]


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An introduction to Kernel Learning Algorithms

Gehler, P., Schölkopf, B.

In Kernel Methods for Remote Sensing Data Analysis, pages: 25-48, 2, (Editors: Gustavo Camps-Valls and Lorenzo Bruzzone), Wiley, New York, NY, USA, 2009 (inbook)

Abstract
Kernel learning algorithms are currently becoming a standard tool in the area of machine learning and pattern recognition. In this chapter we review the fundamental theory of kernel learning. As the basic building block we introduce the kernel function, which provides an elegant and general way to compare possibly very complex objects. We then review the concept of a reproducing kernel Hilbert space and state the representer theorem. Finally we give an overview of the most prominent algorithms, which are support vector classification and regression, Gaussian Processes and kernel principal analysis. With multiple kernel learning and structured output prediction we also introduce some more recent advancements in the field.

link (url) DOI [BibTex]

link (url) DOI [BibTex]

2006


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A Kernel Method for the Two-Sample-Problem

Gretton, A., Borgwardt, K., Rasch, M., Schölkopf, B., Smola, A.

20th Annual Conference on Neural Information Processing Systems (NIPS), December 2006 (talk)

Abstract
We propose two statistical tests to determine if two samples are from different distributions. Our test statistic is in both cases the distance between the means of the two samples mapped into a reproducing kernel Hilbert space (RKHS). The first test is based on a large deviation bound for the test statistic, while the second is based on the asymptotic distribution of this statistic. We show that the test statistic can be computed in $O(m^2)$ time. We apply our approach to a variety of problems, including attribute matching for databases using the Hungarian marriage method, where our test performs strongly. We also demonstrate excellent performance when comparing distributions over graphs, for which no alternative tests currently exist.

PDF [BibTex]

2006

PDF [BibTex]


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Ab-initio gene finding using machine learning

Schweikert, G., Zeller, G., Zien, A., Ong, C., de Bona, F., Sonnenburg, S., Phillips, P., Rätsch, G.

NIPS Workshop on New Problems and Methods in Computational Biology, December 2006 (talk)

Web [BibTex]

Web [BibTex]


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Reinforcement Learning by Reward-Weighted Regression

Peters, J.

NIPS Workshop: Towards a New Reinforcement Learning? , December 2006 (talk)

Web [BibTex]

Web [BibTex]


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Graph boosting for molecular QSAR analysis

Saigo, H., Kadowaki, T., Kudo, T., Tsuda, K.

NIPS Workshop on New Problems and Methods in Computational Biology, December 2006 (talk)

Abstract
We propose a new boosting method that systematically combines graph mining and mathematical programming-based machine learning. Informative and interpretable subgraph features are greedily found by a series of graph mining calls. Due to our mathematical programming formulation, subgraph features and pre-calculated real-valued features are seemlessly integrated. We tested our algorithm on a quantitative structure-activity relationship (QSAR) problem, which is basically a regression problem when given a set of chemical compounds. In benchmark experiments, the prediction accuracy of our method favorably compared with the best results reported on each dataset.

Web [BibTex]

Web [BibTex]


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Inferring Causal Directions by Evaluating the Complexity of Conditional Distributions

Sun, X., Janzing, D., Schölkopf, B.

NIPS Workshop on Causality and Feature Selection, December 2006 (talk)

Abstract
We propose a new approach to infer the causal structure that has generated the observed statistical dependences among n random variables. The idea is that the factorization of the joint measure of cause and effect into P(cause)P(effect|cause) leads typically to simpler conditionals than non-causal factorizations. To evaluate the complexity of the conditionals we have tried two methods. First, we have compared them to those which maximize the conditional entropy subject to the observed first and second moments since we consider the latter as the simplest conditionals. Second, we have fitted the data with conditional probability measures being exponents of functions in an RKHS space and defined the complexity by a Hilbert-space semi-norm. Such a complexity measure has several properties that are useful for our purpose. We describe some encouraging results with both methods applied to real-world data. Moreover, we have combined constraint-based approaches to causal discovery (i.e., methods using only information on conditional statistical dependences) with our method in order to distinguish between causal hypotheses which are equivalent with respect to the imposed independences. Furthermore, we compare the performance to Bayesian approaches to causal inference.

Web [BibTex]


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Learning Optimal EEG Features Across Time, Frequency and Space

Farquhar, J., Hill, J., Schölkopf, B.

NIPS Workshop on Current Trends in Brain-Computer Interfacing, December 2006 (talk)

PDF Web [BibTex]

PDF Web [BibTex]


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Semi-Supervised Learning

Zien, A.

Advanced Methods in Sequence Analysis Lectures, November 2006 (talk)

Web [BibTex]

Web [BibTex]


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Prediction of Protein Function from Networks

Shin, H., Tsuda, K.

In Semi-Supervised Learning, pages: 361-376, Adaptive Computation and Machine Learning, (Editors: Chapelle, O. , B. Schölkopf, A. Zien), MIT Press, Cambridge, MA, USA, November 2006 (inbook)

Abstract
In computational biology, it is common to represent domain knowledge using graphs. Frequently there exist multiple graphs for the same set of nodes, representing information from different sources, and no single graph is sufficient to predict class labels of unlabelled nodes reliably. One way to enhance reliability is to integrate multiple graphs, since individual graphs are partly independent and partly complementary to each other for prediction. In this chapter, we describe an algorithm to assign weights to multiple graphs within graph-based semi-supervised learning. Both predicting class labels and searching for weights for combining multiple graphs are formulated into one convex optimization problem. The graph-combining method is applied to functional class prediction of yeast proteins.When compared with individual graphs, the combined graph with optimized weights performs significantly better than any single graph.When compared with the semidefinite programming-based support vector machine (SDP/SVM), it shows comparable accuracy in a remarkably short time. Compared with a combined graph with equal-valued weights, our method could select important graphs without loss of accuracy, which implies the desirable property of integration with selectivity.

Web [BibTex]

Web [BibTex]


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Discrete Regularization

Zhou, D., Schölkopf, B.

In Semi-supervised Learning, pages: 237-250, Adaptive computation and machine learning, (Editors: O Chapelle and B Schölkopf and A Zien), MIT Press, Cambridge, MA, USA, November 2006 (inbook)

Abstract
Many real-world machine learning problems are situated on finite discrete sets, including dimensionality reduction, clustering, and transductive inference. A variety of approaches for learning from finite sets has been proposed from different motivations and for different problems. In most of those approaches, a finite set is modeled as a graph, in which the edges encode pairwise relationships among the objects in the set. Consequently many concepts and methods from graph theory are adopted. In particular, the graph Laplacian is widely used. In this chapter we present a systemic framework for learning from a finite set represented as a graph. We develop discrete analogues of a number of differential operators, and then construct a discrete analogue of classical regularization theory based on those discrete differential operators. The graph Laplacian based approaches are special cases of this general discrete regularization framework. An important thing implied in this framework is that we have a wide choices of regularization on graph in addition to the widely-used graph Laplacian based one.

PDF Web [BibTex]

PDF Web [BibTex]


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A Machine Learning Approach for Determining the PET Attenuation Map from Magnetic Resonance Images

Hofmann, M., Steinke, F., Judenhofer, M., Claussen, C., Schölkopf, B., Pichler, B.

IEEE Medical Imaging Conference, November 2006 (talk)

Abstract
A promising new combination in multimodality imaging is MR-PET, where the high soft tissue contrast of Magnetic Resonance Imaging (MRI) and the functional information of Positron Emission Tomography (PET) are combined. Although many technical problems have recently been solved, it is still an open problem to determine the attenuation map from the available MR scan, as the MR intensities are not directly related to the attenuation values. One standard approach is an atlas registration where the atlas MR image is aligned with the patient MR thus also yielding an attenuation image for the patient. We also propose another approach, which to our knowledge has not been tried before: Using Support Vector Machines we predict the attenuation value directly from the local image information. We train this well-established machine learning algorithm using small image patches. Although both approaches sometimes yielded acceptable results, they also showed their specific shortcomings: The registration often fails with large deformations whereas the prediction approach is problematic when the local image structure is not characteristic enough. However, the failures often do not coincide and integration of both information sources is promising. We therefore developed a combination method extending Support Vector Machines to use not only local image structure but also atlas registered coordinates. We demonstrate the strength of this combination approach on a number of examples.

[BibTex]

[BibTex]


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Semi-Supervised Support Vector Machines and Application to Spam Filtering

Zien, A.

ECML Discovery Challenge Workshop, September 2006 (talk)

Abstract
After introducing the semi-supervised support vector machine (aka TSVM for "transductive SVM"), a few popular training strategies are briefly presented. Then the assumptions underlying semi-supervised learning are reviewed. Finally, two modern TSVM optimization techniques are applied to the spam filtering data sets of the workshop; it is shown that they can achieve excellent results, if the problem of the data being non-iid can be handled properly.

PDF Web [BibTex]


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Inferential Structure Determination: Probabilistic determination and validation of NMR structures

Habeck, M.

Gordon Research Conference on Computational Aspects of Biomolecular NMR, September 2006 (talk)

Web [BibTex]

Web [BibTex]


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Machine Learning Algorithms for Polymorphism Detection

Schweikert, G., Zeller, G., Clark, R., Ossowski, S., Warthmann, N., Shinn, P., Frazer, K., Ecker, J., Huson, D., Weigel, D., Schölkopf, B., Rätsch, G.

2nd ISCB Student Council Symposium, August 2006 (talk)

Abstract
Analyzing resequencing array data using machine learning, we obtain a genome-wide inventory of polymorphisms in 20 wild strains of Arabidopsis thaliana, including 750,000 single nucleotide poly- morphisms (SNPs) and thousands of highly polymorphic regions and deletions. We thus provide an unprecedented resource for the study of natural variation in plants.

Web [BibTex]

Web [BibTex]