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2015


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Diversity of sharp wave-ripples in the CA1 of the macaque hippocampus and their brain wide signatures

Ramirez-Villegas, J. F., Logothetis, N. K., Besserve, M.

45th Annual Meeting of the Society for Neuroscience (Neuroscience 2015), October 2015 (poster)

link (url) [BibTex]

2015

link (url) [BibTex]


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Retrospective rigid motion correction of undersampled MRI data

Loktyushin, A., Babayeva, M., Gallichan, D., Krueger, G., Scheffler, K., Kober, T.

23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine, ISMRM, June 2015 (poster)

[BibTex]

[BibTex]


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Improving Quantitative Susceptibility and R2* Mapping by Applying Retrospective Motion Correction

Feng, X., Loktyushin, A., Deistung, A., Reichenbach, J. R.

23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine, ISMRM, June 2015 (poster)

[BibTex]

[BibTex]


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Increasing the sensitivity of Kepler to Earth-like exoplanets

Foreman-Mackey, D., Hogg, D., Schölkopf, B., Wang, D.

Workshop: 225th American Astronomical Society Meeting 2015 , pages: 105.01D, 2015 (poster)

Web link (url) [BibTex]

Web link (url) [BibTex]


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Calibrating the pixel-level Kepler imaging data with a causal data-driven model

Wang, D., Foreman-Mackey, D., Hogg, D., Schölkopf, B.

Workshop: 225th American Astronomical Society Meeting 2015 , pages: 258.08, 2015 (poster)

Web link (url) [BibTex]

Web link (url) [BibTex]


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Assessment of tumor heterogeneity using unsupervised graph based clustering of multi-modality imaging data

Katiyar, P., Divine, M. R., Pichler, B. J., Disselhorst, J. A.

European Molecular Imaging Meeting, 2015 (poster)

[BibTex]

[BibTex]


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Disparity estimation from a generative light field model

Köhler, R., Schölkopf, B., Hirsch, M.

IEEE International Conference on Computer Vision (ICCV 2015), Workshop on Inverse Rendering, 2015, Note: This work has been presented as a poster and is not included in the workshop proceedings. (poster)

[BibTex]

[BibTex]

2011


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Optimization for Machine Learning

Sra, S., Nowozin, S., Wright, S.

pages: 494, Neural information processing series, MIT Press, Cambridge, MA, USA, December 2011 (book)

Abstract
The interplay between optimization and machine learning is one of the most important developments in modern computational science. Optimization formulations and methods are proving to be vital in designing algorithms to extract essential knowledge from huge volumes of data. Machine learning, however, is not simply a consumer of optimization technology but a rapidly evolving field that is itself generating new optimization ideas. This book captures the state of the art of the interaction between optimization and machine learning in a way that is accessible to researchers in both fields. Optimization approaches have enjoyed prominence in machine learning because of their wide applicability and attractive theoretical properties. The increasing complexity, size, and variety of today's machine learning models call for the reassessment of existing assumptions. This book starts the process of reassessment. It describes the resurgence in novel contexts of established frameworks such as first-order methods, stochastic approximations, convex relaxations, interior-point methods, and proximal methods. It also devotes attention to newer themes such as regularized optimization, robust optimization, gradient and subgradient methods, splitting techniques, and second-order methods. Many of these techniques draw inspiration from other fields, including operations research, theoretical computer science, and subfields of optimization. The book will enrich the ongoing cross-fertilization between the machine learning community and these other fields, and within the broader optimization community.

Web [BibTex]

2011

Web [BibTex]


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Spatiotemporal mapping of rhythmic activity in the inferior convexity of the macaque prefrontal cortex

Panagiotaropoulos, T., Besserve, M., Crocker, B., Kapoor, V., Tolias, A., Panzeri, S., Logothetis, N.

41(239.15), 41st Annual Meeting of the Society for Neuroscience (Neuroscience), November 2011 (poster)

Abstract
The inferior convexity of the macaque prefrontal cortex (icPFC) is known to be involved in higher order processing of sensory information mediating stimulus selection, attention and working memory. Until now, the vast majority of electrophysiological investigations of the icPFC employed single electrode recordings. As a result, relatively little is known about the spatiotemporal structure of neuronal activity in this cortical area. Here we study in detail the spatiotemporal properties of local field potentials (LFP's) in the icPFC using multi electrode recordings during anesthesia. We computed the LFP-LFP coherence as a function of frequency for thousands of pairs of simultaneously recorded sites anterior to the arcuate and inferior to the principal sulcus. We observed two distinct peaks of coherent oscillatory activity between approximately 4-10 and 15-25 Hz. We then quantified the instantaneous phase of these frequency bands using the Hilbert transform and found robust phase gradients across recording sites. The dependency of the phase on the spatial location reflects the existence of traveling waves of electrical activity in the icPFC. The dominant axis of these traveling waves roughly followed the ventral-dorsal plane. Preliminary results show that repeated visual stimulation with a 10s movie had no dramatic effect on the spatial structure of the traveling waves. Traveling waves of electrical activity in the icPFC could reflect highly organized cortical processing in this area of prefrontal cortex.

Web [BibTex]

Web [BibTex]


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Evaluation and Optimization of MR-Based Attenuation Correction Methods in Combined Brain PET/MR

Mantlik, F., Hofmann, M., Bezrukov, I., Schmidt, H., Kolb, A., Beyer, T., Reimold, M., Schölkopf, B., Pichler, B.

2011(MIC18.M-96), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (poster)

Abstract
Combined PET/MR provides simultaneous molecular and functional information in an anatomical context with unique soft tissue contrast. However, PET/MR does not support direct derivation of attenuation maps of objects and tissues within the measured PET field-of-view. Valid attenuation maps are required for quantitative PET imaging, specifically for scientific brain studies. Therefore, several methods have been proposed for MR-based attenuation correction (MR-AC). Last year, we performed an evaluation of different MR-AC methods, including simple MR thresholding, atlas- and machine learning-based MR-AC. CT-based AC served as gold standard reference. RoIs from 2 anatomic brain atlases with different levels of detail were used for evaluation of correction accuracy. We now extend our evaluation of different MR-AC methods by using an enlarged dataset of 23 patients from the integrated BrainPET/MR (Siemens Healthcare). Further, we analyze options for improving the MR-AC performance in terms of speed and accuracy. Finally, we assess the impact of ignoring BrainPET positioning aids during the course of MR-AC. This extended study confirms the overall prediction accuracy evaluation results of the first evaluation in a larger patient population. Removing datasets affected by metal artifacts from the Atlas-Patch database helped to improve prediction accuracy, although the size of the database was reduced by one half. Significant improvement in prediction speed can be gained at a cost of only slightly reduced accuracy, while further optimizations are still possible.

Web [BibTex]

Web [BibTex]


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Atlas- and Pattern Recognition Based Attenuation Correction on Simultaneous Whole-Body PET/MR

Bezrukov, I., Schmidt, H., Mantlik, F., Schwenzer, N., Hofmann, M., Schölkopf, B., Pichler, B.

2011(MIC18.M-116), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (poster)

Abstract
With the recent availability of clinical whole-body PET/MRI it is possible to evaluate and further develop MR-based attenuation correction methods using simultaneously acquired PET/MR data. We present first results for MRAC on patient data acquired on a fully integrated whole-body PET/MRI (Biograph mMR, Siemens) using our method that applies atlas registration and pattern recognition (ATPR) and compare them to the segmentation-based (SEG) method provided by the manufacturer. The ATPR method makes use of a database of previously aligned pairs of MR-CT volumes to predict attenuation values on a continuous scale. The robustness of the method in presence of MR artifacts was improved by location and size based detection. Lesion to liver and lesion to blood ratios (LLR and LBR) were compared for both methods on 29 iso-contour ROIs in 4 patients. ATPR showed >20% higher LBR and LLR for ROIs in and >7% near osseous tissue. For ROIs in soft tissue, both methods yielded similar ratios with max. differences <6% . For ROIs located within metal artifacts in the MR image, ATPR showed >190% higher LLR and LBR than SEG, where ratios <0.1 occured. For lesions in the neighborhood of artifacts, both ratios were >15% higher for ATPR. If artifacts in MR volumes caused by metal implants are not accounted for in the computation of attenuation maps, they can lead to a strong decrease of lesion to background ratios, even to disappearance of hot spots. Metal implants are likely to occur in the patient collective receiving combined PET/MR scans, of our first 10 patients, 3 had metal implants. Our method is currently able to account for artifacts in the pelvis caused by prostheses. The ability of the ATPR method to account for bone leads to a significant increase of LLR and LBR in osseous tissue, which supports our previous evaluations with combined PET/CT and PET/MR data. For lesions within soft tissue, lesion to background ratios of ATPR and SEG were comparable.

Web [BibTex]

Web [BibTex]


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Retrospective blind motion correction of MR images

Loktyushin, A., Nickisch, H., Pohmann, R.

Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):498, 28th Annual Scientific Meeting ESMRMB, October 2011 (poster)

Abstract
We present a retrospective method, which significantly reduces ghosting and blurring artifacts due to subject motion. No modifications to the sequence (as in [2, 3]), or the use of additional equipment (as in [1]) are required. Our method iteratively searches for the transformation, that applied to the lines in k-space -- yields the sparsest Laplacian filter output in the spatial domain.

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


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Model based reconstruction for GRE EPI

Blecher, W., Pohmann, R., Schölkopf, B., Seeger, M.

Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):493-494, 28th Annual Scientific Meeting ESMRMB, October 2011 (poster)

Abstract
Model based nonlinear image reconstruction methods for MRI [3] are at the heart of modern reconstruction techniques (e.g.compressed sensing [6]). In general, models are expressed as a matrix equation where y and u are column vectors of k-space and image data, X model matrix and e independent noise. However, solving the corresponding linear system is not tractable. Therefore fast nonlinear algorithms that minimize a function wrt.the unknown image are the method of choice: In this work a model for gradient echo EPI, is proposed that incorporates N/2 Ghost correction and correction for field inhomogeneities. In addition to reconstruction from full data, the model allows for sparse reconstruction, joint estimation of image, field-, and relaxation-map (like [5,8] for spiral imaging), and improved N/2 ghost correction.

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


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Simultaneous multimodal imaging of patients with bronchial carcinoma in a whole body MR/PET system

Brendle, C., Sauter, A., Schmidt, H., Schraml, C., Bezrukov, I., Martirosian, P., Hetzel, J., Müller, M., Claussen, C., Schwenzer, N., Pfannenberg, C.

Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):141, 28th annual scientific meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRB), October 2011 (poster)

Abstract
Purpose/Introduction: Lung cancer is among the most frequent cancers (1). Exact determination of tumour extent and viability is crucial for adequate therapy guidance. [18F]-FDG-PET allows accurate staging and the evaluation of therapy response based on glucose metabolism. Diffusion weighted MRI (DWI) is another promising tool for the evaluation of tumour viability (2,3). The aim of the study was the simultaneous PET-MR acquisition in lung cancer patients and correlation of PET and MR data. Subjects and Methods: Seven patients (age 38-73 years, mean 61 years) with highly suspected or known bronchial carcinoma were examined. First, a [18F]-FDG-PET/CT was performed (injected dose: 332-380 MBq). Subsequently, patients were examined at the whole-body MR/PET (Siemens Biograph mMR). The MRI is a modified 3T Verio whole body system with a magnet bore of 60 cm (max. amplitude gradients 45 mT/m, max. slew rate 200 T/m/s). Concerning the PET, the whole-body MR/PET system comprises 56 detector cassettes with a 59.4 cm transaxial and 25.8 cm axial FoV. The following parameters for PET acquisition were applied: 2 bed positions, 6 min/bed with an average uptake time of 124 min after injection (range: 110-143 min). The attenuation correction of PET data was conducted with a segmentation-based method provided by the manufacturer. Acquired PET data were reconstructed with an iterative 3D OSEM algorithm using 3 iterations and 21 subsets, Gaussian filter of 3 mm. DWI MR images were recorded simultaneously for each bed using two b-values (0/800 s/mm2). SUVmax and ADCmin were assessed in a ROI analysis. The following ratios were calculated: SUVmax(tumor)/SUVmean(liver) and ADCmin(tumor)/ADCmean(muscle). Correlation between SUV and ADC was analyzed (Pearson’s correlation). Results: Diagnostic scans could be obtained in all patients with good tumour delineation. The spatial matching of PET and DWI data was very exact. Most tumours showed a pronounced FDG-uptake in combination with decreased ADC values. Significant correlation was found between SUV and ADC ratios (r = -0.87, p = 0.0118). Discussion/Conclusion: Simultaneous MR/PET imaging of lung cancer is feasible. The whole-body MR/PET system can provide complementary information regarding tumour viability and cellularity which could facilitate a more profound tumour characterization. Further studies have to be done to evaluate the importance of these parameters for therapy decisions and monitoring

Web DOI [BibTex]

Web DOI [BibTex]


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Bayesian Time Series Models

Barber, D., Cemgil, A., Chiappa, S.

pages: 432, Cambridge University Press, Cambridge, UK, August 2011 (book)

[BibTex]

[BibTex]


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Support Vector Machines for finding deletions and short insertions using paired-end short reads

Grimm, D., Hagmann, J., König, D., Weigel, D., Borgwardt, KM.

International Conference on Intelligent Systems for Molecular Biology (ISMB), 2011 (poster)

Web [BibTex]

Web [BibTex]


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Handbook of Statistical Bioinformatics

Lu, H., Schölkopf, B., Zhao, H.

pages: 627, Springer Handbooks of Computational Statistics, Springer, Berlin, Germany, 2011 (book)

Web DOI [BibTex]

Web DOI [BibTex]


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Statistical estimation for optimization problems on graphs

Langovoy, M., Sra, S.

Empirical Inference Symposium, 2011 (poster)

[BibTex]


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Transfer Learning with Copulas

Lopez-Paz, D., Hernandez-Lobato, J.

Neural Information Processing Systems (NIPS), 2011 (poster)

PDF [BibTex]

PDF [BibTex]

2008


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Variational Bayesian Model Selection in Linear Gaussian State-Space based Models

Chiappa, S.

International Workshop on Flexible Modelling: Smoothing and Robustness (FMSR 2008), 2008, pages: 1, November 2008 (poster)

Web [BibTex]

2008

Web [BibTex]


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Towards the neural basis of the flash-lag effect

Ecker, A., Berens, P., Hoenselaar, A., Subramaniyan, M., Tolias, A., Bethge, M.

International Workshop on Aspects of Adaptive Cortex Dynamics, 2008, pages: 1, September 2008 (poster)

PDF [BibTex]

PDF [BibTex]


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Policy Learning: A Unified Perspective With Applications In Robotics

Peters, J., Kober, J., Nguyen-Tuong, D.

8th European Workshop on Reinforcement Learning for Robotics (EWRL 2008), 8, pages: 10, July 2008 (poster)

Abstract
Policy Learning approaches are among the best suited methods for high-dimensional, continuous control systems such as anthropomorphic robot arms and humanoid robots. In this paper, we show two contributions: firstly, we show a unified perspective which allows us to derive several policy learning al- gorithms from a common point of view, i.e, policy gradient algorithms, natural- gradient algorithms and EM-like policy learning. Secondly, we present several applications to both robot motor primitive learning as well as to robot control in task space. Results both from simulation and several different real robots are shown.

PDF [BibTex]

PDF [BibTex]


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Reinforcement Learning of Perceptual Coupling for Motor Primitives

Kober, J., Peters, J.

8th European Workshop on Reinforcement Learning for Robotics (EWRL 2008), 8, pages: 16, July 2008 (poster)

Abstract
Reinforcement learning is a natural choice for the learning of complex motor tasks by reward-related self-improvement. As the space of movements is high-dimensional and continuous, a policy parametrization is needed which can be used in this context. Traditional motor primitive approaches deal largely with open-loop policies which can only deal with small perturbations. In this paper, we present a new type of motor primitive policies which serve as closed-loop policies together with an appropriate learning algorithm. Our new motor primitives are an augmented version version of the dynamic systems motor primitives that incorporates perceptual coupling to external variables. We show that these motor primitives can perform complex tasks such a Ball-in-a-Cup or Kendama task even with large variances in the initial conditions where a human would hardly be able to learn this task. We initialize the open-loop policies by imitation learning and the perceptual coupling with a handcrafted solution. We first improve the open-loop policies and subsequently the perceptual coupling using a novel reinforcement learning method which is particularly well-suited for motor primitives.

PDF [BibTex]

PDF [BibTex]


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Flexible Models for Population Spike Trains

Bethge, M., Macke, J., Berens, P., Ecker, A., Tolias, A.

AREADNE 2008: Research in Encoding and Decoding of Neural Ensembles, 2, pages: 52, June 2008 (poster)

PDF [BibTex]

PDF [BibTex]


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Pairwise Correlations and Multineuronal Firing Patterns in the Primary Visual Cortex of the Awake, Behaving Macaque

Berens, P., Ecker, A., Subramaniyan, M., Macke, J., Hauck, P., Bethge, M., Tolias, A.

AREADNE 2008: Research in Encoding and Decoding of Neural Ensembles, 2, pages: 48, June 2008 (poster)

PDF [BibTex]

PDF [BibTex]


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Visual saliency re-visited: Center-surround patterns emerge as optimal predictors for human fixation targets

Wichmann, F., Kienzle, W., Schölkopf, B., Franz, M.

Journal of Vision, 8(6):635, 8th Annual Meeting of the Vision Sciences Society (VSS), June 2008 (poster)

Abstract
Humans perceives the world by directing the center of gaze from one location to another via rapid eye movements, called saccades. In the period between saccades the direction of gaze is held fixed for a few hundred milliseconds (fixations). It is primarily during fixations that information enters the visual system. Remarkably, however, after only a few fixations we perceive a coherent, high-resolution scene despite the visual acuity of the eye quickly decreasing away from the center of gaze: This suggests an effective strategy for selecting saccade targets. Top-down effects, such as the observer's task, thoughts, or intentions have an effect on saccadic selection. Equally well known is that bottom-up effects-local image structure-influence saccade targeting regardless of top-down effects. However, the question of what the most salient visual features are is still under debate. Here we model the relationship between spatial intensity patterns in natural images and the response of the saccadic system using tools from machine learning. This allows us to identify the most salient image patterns that guide the bottom-up component of the saccadic selection system, which we refer to as perceptive fields. We show that center-surround patterns emerge as the optimal solution to the problem of predicting saccade targets. Using a novel nonlinear system identification technique we reduce our learned classifier to a one-layer feed-forward network which is surprisingly simple compared to previously suggested models assuming more complex computations such as multi-scale processing, oriented filters and lateral inhibition. Nevertheless, our model is equally predictive and generalizes better to novel image sets. Furthermore, our findings are consistent with neurophysiological hardware in the superior colliculus. Bottom-up visual saliency may thus not be computed cortically as has been thought previously.

Web DOI [BibTex]

Web DOI [BibTex]


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Analysis of Pattern Recognition Methods in Classifying Bold Signals in Monkeys at 7-Tesla

Ku, S., Gretton, A., Macke, J., Tolias, A., Logothetis, N.

AREADNE 2008: Research in Encoding and Decoding of Neural Ensembles, 2, pages: 67, June 2008 (poster)

Abstract
Pattern recognition methods have shown that fMRI data can reveal significant information about brain activity. For example, in the debate of how object-categories are represented in the brain, multivariate analysis has been used to provide evidence of distributed encoding schemes. Many follow-up studies have employed different methods to analyze human fMRI data with varying degrees of success. In this study we compare four popular pattern recognition methods: correlation analysis, support-vector machines (SVM), linear discriminant analysis and Gaussian naïve Bayes (GNB), using data collected at high field (7T) with higher resolution than usual fMRI studies. We investigate prediction performance on single trials and for averages across varying numbers of stimulus presentations. The performance of the various algorithms depends on the nature of the brain activity being categorized: for several tasks, many of the methods work well, whereas for others, no methods perform above chance level. An important factor in overall classification performance is careful preprocessing of the data, including dimensionality reduction, voxel selection, and outlier elimination.

[BibTex]

[BibTex]


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Machine Learning for Robotics: Learning Methods for Robot Motor Skills

Peters, J.

pages: 107 , (Editors: J Peters), VDM-Verlag, Saarbrücken, Germany, May 2008 (book)

Abstract
Autonomous robots have been a vision of robotics, artificial intelligence, and cognitive sciences. An important step towards this goal is to create robots that can learn to accomplish amultitude of different tasks triggered by environmental context and higher-level instruction. Early approaches to this goal during the heydays of artificial intelligence research in the late 1980s showed that handcrafted approaches do not suffice and that machine learning is needed. However, off the shelf learning techniques often do not scale into real-time or to the high-dimensional domains of manipulator and humanoid robotics. In this book, we investigate the foundations for a general approach to motor skilllearning that employs domain-specific machine learning methods. A theoretically well-founded general approach to representing the required control structures for task representation and executionis presented along with novel learning algorithms that can be applied in this setting. The resulting framework is shown to work well both in simulation and on real robots.

Web [BibTex]

Web [BibTex]


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The role of stimulus correlations for population decoding in the retina

Schwartz, G., Macke, J., Berry, M.

Computational and Systems Neuroscience 2008 (COSYNE 2008), 5, pages: 172, March 2008 (poster)

PDF Web [BibTex]

PDF Web [BibTex]

2002


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Real-Time Statistical Learning for Oculomotor Control and Visuomotor Coordination

Vijayakumar, S., Souza, A., Peters, J., Conradt, J., Rutkowski, T., Ijspeert, A., Nakanishi, J., Inoue, M., Shibata, T., Wiryo, A., Itti, L., Amari, S., Schaal, S.

(Editors: Becker, S. , S. Thrun, K. Obermayer), Sixteenth Annual Conference on Neural Information Processing Systems (NIPS), December 2002 (poster)

Web [BibTex]

2002

Web [BibTex]


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Learning with Kernels: Support Vector Machines, Regularization, Optimization, and Beyond

Schölkopf, B., Smola, A.

pages: 644, Adaptive Computation and Machine Learning, MIT Press, Cambridge, MA, USA, December 2002, Parts of this book, including an introduction to kernel methods, can be downloaded here. (book)

Abstract
In the 1990s, a new type of learning algorithm was developed, based on results from statistical learning theory: the Support Vector Machine (SVM). This gave rise to a new class of theoretically elegant learning machines that use a central concept of SVMs-kernels—for a number of learning tasks. Kernel machines provide a modular framework that can be adapted to different tasks and domains by the choice of the kernel function and the base algorithm. They are replacing neural networks in a variety of fields, including engineering, information retrieval, and bioinformatics. Learning with Kernels provides an introduction to SVMs and related kernel methods. Although the book begins with the basics, it also includes the latest research. It provides all of the concepts necessary to enable a reader equipped with some basic mathematical knowledge to enter the world of machine learning using theoretically well-founded yet easy-to-use kernel algorithms and to understand and apply the powerful algorithms that have been developed over the last few years.

Web [BibTex]

Web [BibTex]


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Surface-slant-from-texture discrimination: Effects of slant level and texture type

Rosas, P., Wichmann, F., Wagemans, J.

Journal of Vision, 2(7):300, Second Annual Meeting of the Vision Sciences Society (VSS), November 2002 (poster)

Abstract
The problem of surface-slant-from-texture was studied psychophysically by measuring the performances of five human subjects in a slant-discrimination task with a number of different types of textures: uniform lattices, randomly displaced lattices, polka dots, Voronoi tessellations, orthogonal sinusoidal plaid patterns, fractal or 1/f noise, “coherent” noise and a “diffusion-based” texture (leopard skin-like). The results show: (1) Improving performance with larger slants for all textures. (2) A “non-symmetrical” performance around a particular slant characterized by a psychometric function that is steeper in the direction of the more slanted orientation. (3) For sufficiently large slants (66 deg) there are no major differences in performance between any of the different textures. (4) For slants at 26, 37 and 53 degrees, however, there are marked differences between the different textures. (5) The observed differences in performance across textures for slants up to 53 degrees are systematic within subjects, and nearly so across them. This allows a rank-order of textures to be formed according to their “helpfulness” — that is, how easy the discrimination task is when a particular texture is mapped on the surface. Polka dots tended to allow the best slant discrimination performance, noise patterns the worst up to the large slant of 66 degrees at which performance was almost independent of the particular texture chosen. Finally, our large number of 2AFC trials (approximately 2800 trials per texture across subjects) and associated tight confidence intervals may enable us to find out about which statistical properties of the textures could be responsible for surface-slant-from-texture estimation, with the ultimate goal of being able to predict observer performance for any arbitrary texture.

Web DOI [BibTex]

Web DOI [BibTex]


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Modelling Contrast Transfer in Spatial Vision

Wichmann, F.

Journal of Vision, 2(10):7, Second Annual Meeting of the Vision Sciences Society (VSS), November 2002 (poster)

Abstract
Much of our information about spatial vision comes from detection experiments involving low-contrast stimuli. Contrast discrimination experiments provide one way to explore the visual system's response to stimuli of higher contrast, the results of which allow different models of contrast processing (e.g. energy versus gain-control models) to be critically assessed (Wichmann & Henning, 1999). Studies of detection and discrimination using pulse train stimuli in noise, on the other hand, make predictions about the number, position and properties of noise sources within the processing stream (Henning, Bird & Wichmann, 2002). Here I report modelling results combining data from both sinusoidal and pulse train experiments in and without noise to arrive at a more tightly constrained model of early spatial vision.

Web DOI [BibTex]

Web DOI [BibTex]


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Pulse train detection and discrimination in pink noise

Henning, G., Wichmann, F., Bird, C.

Journal of Vision, 2(7):229, Second Annual Meeting of the Vision Sciences Society (VSS), November 2002 (poster)

Abstract
Much of our information about spatial vision comes from detection experiments involving low-contrast stimuli. Contrast discrimination experiments provide one way to explore the visual system's response to stimuli of higher contrast. We explored both detection and contrast discrimination performance with sinusoidal and "pulse-train" (or line) gratings. Both types of grating had a fundamental spatial frequency of 2.09-c/deg but the pulse-train, ideally, contains, in addition to its fundamental component, all the harmonics of the fundamental. Although the 2.09-c/deg pulse-train produced on the display was measured and shown to contain at least 8 harmonics at equal contrast, it was no more detectable than its most detectable component; no benefit from having additional information at the harmonics was measurable. The addition of broadband "pink" noise, designed to equalize the detectability of the components of the pulse train, made it about a factor of four more detectable than any of its components. However, in contrast-discrimination experiments, with an in-phase pedestal or masking grating of the same form and phase as the signal and 15% contrast, the noise did not improve the discrimination performance of the pulse train relative to that of its sinusoidal components. In contrast, a 2.09-c/deg "super train," constructed to have 8 equally detectable harmonics, was a factor of five more detectable than any of its components. We discuss the implications of these observations for models of early vision in particular the implications for possible sources of internal noise.

Web DOI [BibTex]

Web DOI [BibTex]


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Phase information in the recognition of natural images

Braun, D., Wichmann, F., Gegenfurtner, K.

Perception, 31(ECVP Abstract Supplement):133, 25th European Conference on Visual Perception, August 2002 (poster)

Abstract
Fourier phase plays an important role in determining global image structure. For example, when the phase spectrum of an image of a flower is swapped with that of a tank, we usually perceive a tank, even though the amplitude spectrum is still that of the flower. Similarly, when the phase spectrum of an image is randomly swapped across frequencies, that is its Fourier energy is randomly distributed over the image, the resulting image becomes impossible to recognise. Our goal was to evaluate the effect of phase manipulations in a quantitative manner. Subjects viewed two images of natural scenes, one of which contained an animal (the target) embedded in the background. The spectra of the images were manipulated by adding random phase noise at each frequency. The phase noise was the independent variable, uniformly distributed between 0° and ±180°. Subjects were remarkably resistant to phase noise. Even with ±120° noise, subjects were still 75% correct. The proportion of correct answers closely followed the correlation between original and noise-distorted images. Thus it appears as if it was not the global phase information per se that determines our percept of natural images, but rather the effect of phase on local image features.

Web [BibTex]

Web [BibTex]


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Detection and discrimination in pink noise

Wichmann, F., Henning, G.

5, pages: 100, 5. T{\"u}binger Wahrnehmungskonferenz (TWK), February 2002 (poster)

Abstract
Much of our information about early spatial vision comes from detection experiments involving low-contrast stimuli, which are not, perhaps, particularly "natural" stimuli. Contrast discrimination experiments provide one way to explore the visual system's response to stimuli of higher contrast whilst keeping the number of unknown parameters comparatively small. We explored both detection and contrast discrimination performance with sinusoidal and "pulse-train" (or line) gratings. Both types of grating had a fundamental spatial frequency of 2.09-c/deg but the pulse-train, ideally, contains, in addition to its fundamental component, all the harmonics of the fundamental. Although the 2.09-c/deg pulse-train produced on our display was measured using a high-performance digital camera (Photometrics) and shown to contain at least 8 harmonics at equal contrast, it was no more detectable than its most detectable component; no benefit from having additional information at the harmonics was measurable. The addition of broadband 1-D "pink" noise made it about a factor of four more detectable than any of its components. However, in contrast-discrimination experiments, with an in-phase pedestal or masking grating of the same form and phase as the signal and 15% contrast, the noise did not improve the discrimination performance of the pulse train relative to that of its sinusoidal components. We discuss the implications of these observations for models of early vision in particular the implications for possible sources of internal noise.

Web [BibTex]

Web [BibTex]


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Application of Monte Carlo Methods to Psychometric Function Fitting

Wichmann, F.

Proceedings of the 33rd European Conference on Mathematical Psychology, pages: 44, 2002 (poster)

Abstract
The psychometric function relates an observer's performance to an independent variable, usually some physical quantity of a stimulus in a psychophysical task. Here I describe methods to (1) fitting psychometric functions, (2) assessing goodness-of-fit, and (3) providing confidence intervals for the function's parameters and other estimates derived from them. First I describe a constrained maximum-likelihood method for parameter estimation. Using Monte-Carlo simulations I demonstrate that it is important to have a fitting method that takes stimulus-independent errors (or "lapses") into account. Second, a number of goodness-of-fit tests are introduced. Because psychophysical data sets are usually rather small I advocate the use of Monte Carlo resampling techniques that do not rely on asymptotic theory for goodness-of-fit assessment. Third, a parametric bootstrap is employed to estimate the variability of fitted parameters and derived quantities such as thresholds and slopes. I describe how the bootstrap bridging assumption, on which the validity of the procedure depends, can be tested without incurring too high a cost in computation time. Finally I describe how the methods can be extended to test hypotheses concerning the form and shape of several psychometric functions. Software describing the methods is available (http://www.bootstrap-software.com/psignifit/), as well as articles describing the methods in detail (Wichmann&Hill, Perception&Psychophysics, 2001a,b).

[BibTex]

[BibTex]


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Optimal linear estimation of self-motion - a real-world test of a model of fly tangential neurons

Franz, MO.

SAB 02 Workshop, Robotics as theoretical biology, 7th meeting of the International Society for Simulation of Adaptive Behaviour (SAB), (Editors: Prescott, T.; Webb, B.), 2002 (poster)

Abstract
The tangential neurons in the fly brain are sensitive to the typical optic flow patterns generated during self-motion (see example in Fig.1). We examine whether a simplified linear model of these neurons can be used to estimate self-motion from the optic flow. We present a theory for the construction of an optimal linear estimator incorporating prior knowledge both about the distance distribution of the environment, and about the noise and self-motion statistics of the sensor. The optimal estimator is tested on a gantry carrying an omnidirectional vision sensor that can be moved along three translational and one rotational degree of freedom. The experiments indicate that the proposed approach yields accurate results for rotation estimates, independently of the current translation and scene layout. Translation estimates, however, turned out to be sensitive to simultaneous rotation and to the particular distance distribution of the scene. The gantry experiments confirm that the receptive field organization of the tangential neurons allows them, as an ensemble, to extract self-motion from the optic flow.

PDF [BibTex]

PDF [BibTex]

2000


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Advances in Large Margin Classifiers

Smola, A., Bartlett, P., Schölkopf, B., Schuurmans, D.

pages: 422, Neural Information Processing, MIT Press, Cambridge, MA, USA, October 2000 (book)

Abstract
The concept of large margins is a unifying principle for the analysis of many different approaches to the classification of data from examples, including boosting, mathematical programming, neural networks, and support vector machines. The fact that it is the margin, or confidence level, of a classification--that is, a scale parameter--rather than a raw training error that matters has become a key tool for dealing with classifiers. This book shows how this idea applies to both the theoretical analysis and the design of algorithms. The book provides an overview of recent developments in large margin classifiers, examines connections with other methods (e.g., Bayesian inference), and identifies strengths and weaknesses of the method, as well as directions for future research. Among the contributors are Manfred Opper, Vladimir Vapnik, and Grace Wahba.

Web [BibTex]

2000

Web [BibTex]


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Contrast discrimination using periodic pulse trains

Wichmann, F., Henning, G.

pages: 74, 3. T{\"u}binger Wahrnehmungskonferenz (TWK), February 2000 (poster)

Abstract
Understanding contrast transduction is essential for understanding spatial vision. Previous research (Wichmann et al. 1998; Wichmann, 1999; Henning and Wichmann, 1999) has demonstrated the importance of high contrasts to distinguish between alternative models of contrast discrimination. However, the modulation transfer function of the eye imposes large contrast losses on stimuli, particularly for stimuli of high spatial frequency, making high retinal contrasts difficult to obtain using sinusoidal gratings. Standard 2AFC contrast discrimination experiments were conducted using periodic pulse trains as stimuli. Given our Mitsubishi display we achieve stimuli with up to 160% contrast at the fundamental frequency. The shape of the threshold versus (pedestal) contrast (TvC) curve using pulse trains shows the characteristic dipper shape, i.e. contrast discrimination is sometimes “easier” than detection. The rising part of the TvC function has the same slope as that measured for contrast discrimination using sinusoidal gratings of the same frequency as the fundamental. Periodic pulse trains offer the possibility to explore the visual system’s properties using high retinal contrasts. Thus they might prove useful in tasks other than contrast discrimination. Second, at least for high spatial frequencies (8 c/deg) it appears that contrast discrimination using sinusoids and periodic pulse trains results in virtually identical TvC functions, indicating a lack of probability summation. Further implications of these results are discussed.

Web [BibTex]

Web [BibTex]


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Subliminale Darbietung verkehrsrelevanter Information in Kraftfahrzeugen

Staedtgen, M., Hahn, S., Franz, MO., Spitzer, M.

pages: 98, (Editors: H.H. Bülthoff, K.R. Gegenfurtner, H.A. Mallot), 3. T{\"u}binger Wahrnehmungskonferenz (TWK), February 2000 (poster)

Abstract
Durch moderne Bildverarbeitungstechnologien ist es m{\"o}glich, in Kraftfahrzeugen bestimmte kritische Verkehrssituationen automatisch zu erkennen und den Fahrer zu warnen bzw. zu informieren. Ein Problem ist dabei die Darbietung der Ergebnisse, die den Fahrer m{\"o}glichst wenig belasten und seine Aufmerksamkeit nicht durch zus{\"a}tzliche Warnleuchten oder akustische Signale vom Verkehrsgeschehen ablenken soll. In einer Reihe von Experimenten wurde deshalb untersucht, ob subliminal dargebotene, das heißt nicht bewußt wahrgenommene, verkehrsrelevante Informationen verhaltenswirksam werden und zur Informations{\"u}bermittlung an den Fahrer genutzt werden k{\"o}nnen. In einem Experiment zur semantischen Bahnung konnte mit Hilfe einer lexikalischen Entscheidungsaufgabe gezeigt werden, daß auf den Straßenverkehr bezogene Worte schneller verarbeitet werden, wenn vorher ein damit in Zusammenhang stehendes Bild eines Verkehrsschildes subliminal pr{\"a}sentiert wurde. Auch bei parafovealer Darbietung der subliminalen Stimuli wurde eine Beschleunigung erzielt. In einer visuellen Suchaufgabe wurden in Bildern realer Verkehrssituationen Verkehrszeichen schneller entdeckt, wenn das Bild des Verkehrszeichens vorher subliminal dargeboten wurde. In beiden Experimenten betrug die Pr{\"a}sentationszeit f{\"u}r die Hinweisreize 17 ms, zus{\"a}tzlich wurde durch Vorw{\"a}rts- und R{\"u}ckw{\"a}rtsmaskierung die bewußteWahrnehmung verhindert. Diese Laboruntersuchungen zeigten, daß sich auch im Kontext des Straßenverkehrs Beschleunigungen der Informationsverarbeitung durch subliminal dargebotene Stimuli erreichen lassen. In einem dritten Experiment wurde die Darbietung eines subliminalen Hinweisreizes auf die Reaktionszeit beim Bremsen in einem realen Fahrversuch untersucht. Die Versuchspersonen (n=17) sollten so schnell wie m{\"o}glich bremsen, wenn die Bremsleuchten eines im Abstand von 12-15 m voran fahrenden Fahrzeuges aufleuchteten. In 50 von insgesamt 100 Durchg{\"a}ngen wurde ein subliminaler Stimulus (zwei rote Punkte mit einem Zentimeter Durchmesser und zehn Zentimeter Abstand) 150 ms vor Aufleuchten der Bremslichter pr{\"a}sentiert. Die Darbietung erfolgte durch ein im Auto an Stelle des Tachometers integriertes TFT-LCD Display. Im Vergleich zur Reaktion ohne subliminalen Stimulus verk{\"u}rzte sich die Reaktionszeit dadurch signifikant um 51 ms. In den beschriebenen Experimenten konnte gezeigt werden, daß die subliminale Darbietung verkehrsrelevanter Information auch in Kraftfahrzeugen verhaltenswirksam werden kann. In Zukunft k{\"o}nnte durch die Kombination der online-Bildverarbeitung im Kraftfahrzeug mit subliminaler Darbietung der Ergebnisse eine Erh{\"o}hung der Verkehrssicherheit und des Komforts erreicht werden.

Web [BibTex]

Web [BibTex]

1997


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Masking by plaid patterns is not explained by adaptation, simple contrast gain-control or distortion products

Wichmann, F., Tollin, D.

Investigative Ophthamology and Visual Science, 38 (4), pages: S631, 1997 (poster)

[BibTex]

1997

[BibTex]


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Masking by plaid patterns: spatial frequency tuning and contrast dependency

Wichmann, F., Tollin, D.

OSA Conference Program, pages: 97, 1997 (poster)

Abstract
The detectability of horizontally orientated sinusoidal signals at different spatial-frequencies was measured in standard 2AFC - tasks in the presence of two-component plaid patterns of different orientation and contrast. The shape of the resulting masking surface provides insight into, and constrains models of, the underlying masking mechanisms.

[BibTex]

[BibTex]


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Support vector learning

Schölkopf, B.

pages: 173, Oldenbourg, München, Germany, 1997, Zugl.: Berlin, Techn. Univ., Diss., 1997 (book)

PDF GZIP [BibTex]

PDF GZIP [BibTex]