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56 results (View BibTeX file of all listed publications)

2010

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Comparative Quantitative Evaluation of MR-Based Attenuation Correction Methods in Combined Brain PET/MR

Mantlik, F., Hofmann, M., Bezrukov, I., Kolb, A., Beyer, T., Reimold, M., Pichler, B., Schölkopf, B.

2010(M08-4), 2010 Nuclear Science Symposium and Medical Imaging Conference (NSS-MIC), November 2010 (talk)

Abstract
Combined PET/MR provides at the same time molecular and functional imaging as well as excellent soft tissue contrast. It does not allow one to directly measure the attenuation properties of scanned tissues, despite the fact that accurate attenuation maps are necessary for quantitative PET imaging. Several methods have therefore been proposed for MR-based attenuation correction (MR-AC). So far, they have only been evaluated on data acquired from separate MR and PET scanners. We evaluated several MR-AC methods on data from 10 patients acquired on a combined BrainPET/MR scanner. This allowed the consideration of specific PET/MR issues, such as the RF coil that attenuates and scatters 511 keV gammas. We evaluated simple MR thresholding methods as well as atlas and machine learning-based MR-AC. CT-based AC served as gold standard reference. To comprehensively evaluate the MR-AC accuracy, we used RoIs from 2 anatomic brain atlases with different levels of detail. Visual inspection of the PET images indicated that even the basic FLASH threshold MR-AC may be sufficient for several applications. Using a UTE sequence for bone prediction in MR-based thresholding occasionally led to false prediction of bone tissue inside the brain, causing a significant overestimation of PET activity. Although it yielded a lower mean underestimation of activity, it exhibited the highest variance of all methods. The atlas averaging approach had a smaller mean error, but showed high maximum overestimation on the RoIs of the more detailed atlas. The Nave Bayes and Atlas-Patch MR-AC yielded the smallest variance, and the Atlas-Patch also showed the smallest mean error. In conclusion, Atlas-based AC using only MR information on the BrainPET/MR yields a high level of accuracy that is sufficient for clinical quantitative imaging requirements. The Atlas-Patch approach was superior to alternative atlas-based methods, yielding a quantification error below 10% for all RoIs except very small ones.

[BibTex]

2010

Mantlik, F., Hofmann, M., Bezrukov, I., Kolb, A., Beyer, T., Reimold, M., Pichler, B., Schölkopf, B. Comparative Quantitative Evaluation of MR-Based Attenuation Correction Methods in Combined Brain PET/MR 2010(M08-4), 2010 Nuclear Science Symposium and Medical Imaging Conference (NSS-MIC), November 2010 (talk)

[BibTex]

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Bayesian Inference and Experimental Design for Large Generalised Linear Models

Nickisch, H.

Biologische Kybernetik, Technische Universität Berlin, Berlin, Germany, September 2010 (phdthesis)

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Nickisch, H. Bayesian Inference and Experimental Design for Large Generalised Linear Models Biologische Kybernetik, Technische Universität Berlin, Berlin, Germany, September 2010 (phdthesis)

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Statistical image analysis and percolation theory

Davies, P., Langovoy, M., Wittich, O.

73rd Annual Meeting of the Institute of Mathematical Statistics (IMS), August 2010 (talk)

Abstract
We develop a novel method for detection of signals and reconstruction of images in the presence of random noise. The method uses results from percolation theory. We specifically address the problem of detection of objects of unknown shapes in the case of nonparametric noise. The noise density is unknown and can be heavy-tailed. We view the object detection problem as hypothesis testing for discrete statistical inverse problems. We present an algorithm that allows to detect objects of various shapes in noisy images. We prove results on consistency and algorithmic complexity of our procedures.

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Davies, P., Langovoy, M., Wittich, O. Statistical image analysis and percolation theory 73rd Annual Meeting of the Institute of Mathematical Statistics (IMS), August 2010 (talk)

Web [BibTex]

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Inferring High-Dimensional Causal Relations using Free Probability Theory

Zscheischler, J.

Humboldt Universität Berlin, Germany, August 2010 (diplomathesis)

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Zscheischler, J. Inferring High-Dimensional Causal Relations using Free Probability Theory Humboldt Universität Berlin, Germany, August 2010 (diplomathesis)

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Statistical image analysis and percolation theory

Langovoy, M., Wittich, O.

28th European Meeting of Statisticians (EMS), August 2010 (talk)

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Langovoy, M., Wittich, O. Statistical image analysis and percolation theory 28th European Meeting of Statisticians (EMS), August 2010 (talk)

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Cooperative Cuts: Graph Cuts with Submodular Edge Weights

Jegelka, S., Bilmes, J.

24th European Conference on Operational Research (EURO XXIV), July 2010 (talk)

Abstract
We introduce cooperative cut, a minimum cut problem whose cost is a submodular function on sets of edges: the cost of an edge that is added to a cut set depends on the edges in the set. Applications are e.g. in probabilistic graphical models and image processing. We prove NP hardness and a polynomial lower bound on the approximation factor, and upper bounds via four approximation algorithms based on different techniques. Our additional heuristics have attractive practical properties, e.g., to rely only on standard min-cut. Both our algorithms and heuristics appear to do well in practice.

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Jegelka, S., Bilmes, J. Cooperative Cuts: Graph Cuts with Submodular Edge Weights 24th European Conference on Operational Research (EURO XXIV), July 2010 (talk)

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Semi-supervised Subspace Learning and Application to Human Functional Magnetic Brain Resonance Imaging Data

Shelton, J.

Biologische Kybernetik, Eberhard Karls Universität, Tübingen, Germany, July 2010 (diplomathesis)

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Shelton, J. Semi-supervised Subspace Learning and Application to Human Functional Magnetic Brain Resonance Imaging Data Biologische Kybernetik, Eberhard Karls Universität, Tübingen, Germany, July 2010 (diplomathesis)

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Solving Large-Scale Nonnegative Least Squares

Sra, S.

16th Conference of the International Linear Algebra Society (ILAS), June 2010 (talk)

Abstract
We study the fundamental problem of nonnegative least squares. This problem was apparently introduced by Lawson and Hanson [1] under the name NNLS. As is evident from its name, NNLS seeks least-squares solutions that are also nonnegative. Owing to its wide-applicability numerous algorithms have been derived for NNLS, beginning from the active-set approach of Lawson and Han- son [1] leading up to the sophisticated interior-point method of Bellavia et al. [2]. We present a new algorithm for NNLS that combines projected subgradients with the non-monotonic gradient descent idea of Barzilai and Borwein [3]. Our resulting algorithm is called BBSG, and we guarantee its convergence by ex- ploiting properties of NNLS in conjunction with projected subgradients. BBSG is surprisingly simple and scales well to large problems. We substantiate our claims by empirically evaluating BBSG and comparing it with established con- vex solvers and specialized NNLS algorithms. The numerical results suggest that BBSG is a practical method for solving large-scale NNLS problems.

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Sra, S. Solving Large-Scale Nonnegative Least Squares 16th Conference of the International Linear Algebra Society (ILAS), June 2010 (talk)

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Matrix Approximation Problems

Sra, S.

EU Regional School: Rheinisch-Westf{\"a}lische Technische Hochschule Aachen, May 2010 (talk)

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Sra, S. Matrix Approximation Problems EU Regional School: Rheinisch-Westf{\"a}lische Technische Hochschule Aachen, May 2010 (talk)

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BCI2000 and Python

Hill, NJ.

Invited lecture at the 7th International BCI2000 Workshop, Pacific Grove, CA, USA, May 2010 (talk)

Abstract
A tutorial, with exercises, on how to integrate your own Python code with the BCI2000 realtime software package.

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Hill, NJ. BCI2000 and Python Invited lecture at the 7th International BCI2000 Workshop, Pacific Grove, CA, USA, May 2010 (talk)

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Extending BCI2000 Functionality with Your Own C++ Code

Hill, NJ.

Invited lecture at the 7th International BCI2000 Workshop, Pacific Grove, CA, USA, May 2010 (talk)

Abstract
A tutorial, with exercises, on how to use BCI2000 C++ framework to write your own real-time signal-processing modules.

[BibTex]

Hill, NJ. Extending BCI2000 Functionality with Your Own C++ Code Invited lecture at the 7th International BCI2000 Workshop, Pacific Grove, CA, USA, May 2010 (talk)

[BibTex]

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Machine-Learning Methods for Decoding Intentional Brain States

Hill, NJ.

Symposium "Non-Invasive Brain Computer Interfaces: Current Developments and Applications" (BIOMAG), March 2010 (talk)

Abstract
Brain-computer interfaces (BCI) work by making the user perform a specific mental task, such as imagining moving body parts or performing some other covert mental activity, or attending to a particular stimulus out of an array of options, in order to encode their intention into a measurable brain signal. Signal-processing and machine-learning techniques are then used to decode the measured signal to identify the encoded mental state and hence extract the user‘s initial intention. The high-noise high-dimensional nature of brain-signals make robust decoding techniques a necessity. Generally, the approach has been to use relatively simple feature extraction techniques, such as template matching and band-power estimation, coupled to simple linear classifiers. This has led to a prevailing view among applied BCI researchers that (sophisticated) machine-learning is irrelevant since “it doesn‘t matter what classifier you use once your features are extracted.” Using examples from our own MEG and EEG experiments, I‘ll demonstrate how machine-learning principles can be applied in order to improve BCI performance, if they are formulated in a domain-specific way. The result is a type of data-driven analysis that is more than “just” classification, and can be used to find better feature extractors.

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Hill, NJ. Machine-Learning Methods for Decoding Intentional Brain States Symposium "Non-Invasive Brain Computer Interfaces: Current Developments and Applications" (BIOMAG), March 2010 (talk)

PDF Web [BibTex]

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PAC-Bayesian Analysis in Unsupervised Learning

Seldin, Y.

Foundations and New Trends of PAC Bayesian Learning Workshop, March 2010 (talk)

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Seldin, Y. PAC-Bayesian Analysis in Unsupervised Learning Foundations and New Trends of PAC Bayesian Learning Workshop, March 2010 (talk)

PDF Web [BibTex]

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Quantitative Evaluation of MR-based Attenuation Correction for Positron Emission Tomography (PET)

Mantlik, F.

Biologische Kybernetik, Universität Mannheim, Germany, March 2010 (diplomathesis)

[BibTex]

Mantlik, F. Quantitative Evaluation of MR-based Attenuation Correction for Positron Emission Tomography (PET) Biologische Kybernetik, Universität Mannheim, Germany, March 2010 (diplomathesis)

[BibTex]

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Learning Motor Primitives for Robotics

Kober, J., Peters, J.

EVENT Lab: Reinforcement Learning in Robotics and Virtual Reality, January 2010 (talk)

Abstract
The acquisition and self-improvement of novel motor skills is among the most important problems in robotics. Motor primitives offer one of the most promising frameworks for the application of machine learning techniques in this context. Employing the Dynamic Systems Motor primitives originally introduced by Ijspeert et al. (2003), appropriate learning algorithms for a concerted approach of both imitation and reinforcement learning are presented. Using these algorithms new motor skills, i.e., Ball-in-a-Cup, Ball-Paddling and Dart-Throwing, are learned.

[BibTex]

Kober, J., Peters, J. Learning Motor Primitives for Robotics EVENT Lab: Reinforcement Learning in Robotics and Virtual Reality, January 2010 (talk)

[BibTex]

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From Motor Learning to Interaction Learning in Robots

Sigaud, O., Peters, J.

pages: 538, Studies in Computational Intelligence ; 264, (Editors: O Sigaud, J Peters), Springer, Berlin, Germany, January 2010 (book)

Abstract
From an engineering standpoint, the increasing complexity of robotic systems and the increasing demand for more autonomously learning robots, has become essential. This book is largely based on the successful workshop "From motor to interaction learning in robots" held at the IEEE/RSJ International Conference on Intelligent Robot Systems. The major aim of the book is to give students interested the topics described above a chance to get started faster and researchers a helpful compandium.

Web DOI [BibTex]

Sigaud, O., Peters, J. From Motor Learning to Interaction Learning in Robots pages: 538, Studies in Computational Intelligence ; 264, (Editors: O Sigaud, J Peters), Springer, Berlin, Germany, January 2010 (book)

Web DOI [BibTex]

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Finding Gene-Gene Interactions using Support Vector Machines

Rakitsch, B.

Eberhard Karls Universität Tübingen, Germany, 2010 (diplomathesis)

[BibTex]

Rakitsch, B. Finding Gene-Gene Interactions using Support Vector Machines Eberhard Karls Universität Tübingen, Germany, 2010 (diplomathesis)

[BibTex]

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Structural and Relational Data Mining for Systems Biology Applications

Georgii, E.

Eberhard Karls Universität Tübingen, Germany , 2010 (phdthesis)

Web [BibTex]

Georgii, E. Structural and Relational Data Mining for Systems Biology Applications Eberhard Karls Universität Tübingen, Germany , 2010 (phdthesis)

Web [BibTex]

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Population Coding in the Visual System: Statistical Methods and Theory

Macke, J.

Eberhard Karls Universität Tübingen, Germany, 2010 (phdthesis)

[BibTex]

Macke, J. Population Coding in the Visual System: Statistical Methods and Theory Eberhard Karls Universität Tübingen, Germany, 2010 (phdthesis)

[BibTex]

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Bayesian Methods for Neural Data Analysis

Gerwinn, S.

Eberhard Karls Universität Tübingen, Germany, 2010 (phdthesis)

Web [BibTex]

Gerwinn, S. Bayesian Methods for Neural Data Analysis Eberhard Karls Universität Tübingen, Germany, 2010 (phdthesis)

Web [BibTex]

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Clustering with Neighborhood Graphs

Maier, M.

Universität des Saarlandes, Saarbrücken, Germany, 2010 (phdthesis)

Web [BibTex]

Maier, M. Clustering with Neighborhood Graphs Universität des Saarlandes, Saarbrücken, Germany, 2010 (phdthesis)

Web [BibTex]

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Detecting the mincut in sparse random graphs

Köhler, R.

Eberhard Karls Universität Tübingen, Germany, 2010 (diplomathesis)

[BibTex]

Köhler, R. Detecting the mincut in sparse random graphs Eberhard Karls Universität Tübingen, Germany, 2010 (diplomathesis)

[BibTex]

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A wider view on encoding and decoding in the visual brain-computer interface speller system

Martens, S.

Eberhard Karls Universität Tübingen, Germany, 2010 (phdthesis)

[BibTex]

2007

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Reaction graph kernels for discovering missing enzymes in the plant secondary metabolism

Saigo, H., Hattori, M., Tsuda, K.

NIPS Workshop on Machine Learning in Computational Biology, December 2007 (talk)

Abstract
Secondary metabolic pathway in plant is important for finding druggable candidate enzymes. However, there are many enzymes whose functions are still undiscovered especially in organism-specific metabolic pathways. We propose reaction graph kernels for automatically assigning the EC numbers to unknown enzymatic reactions in a metabolic network. Experiments are carried out on KEGG/REACTION database and our method successfully predicted the first three digits of the EC number with 83% accuracy.We also exhaustively predicted missing enzymatic functions in the plant secondary metabolism pathways, and evaluated our results in biochemical validity.

Web [BibTex]

2007

Saigo, H., Hattori, M., Tsuda, K. Reaction graph kernels for discovering missing enzymes in the plant secondary metabolism NIPS Workshop on Machine Learning in Computational Biology, December 2007 (talk)

Web [BibTex]

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Positional Oligomer Importance Matrices

Sonnenburg, S., Zien, A., Philips, P., Rätsch, G.

NIPS Workshop on Machine Learning in Computational Biology, December 2007 (talk)

Abstract
At the heart of many important bioinformatics problems, such as gene finding and function prediction, is the classification of biological sequences, above all of DNA and proteins. In many cases, the most accurate classifiers are obtained by training SVMs with complex sequence kernels, for instance for transcription starts or splice sites. However, an often criticized downside of SVMs with complex kernels is that it is very hard for humans to understand the learned decision rules and to derive biological insights from them. To close this gap, we introduce the concept of positional oligomer importance matrices (POIMs) and develop an efficient algorithm for their computation. We demonstrate how they overcome the limitations of sequence logos, and how they can be used to find relevant motifs for different biological phenomena in a straight-forward way. Note that the concept of POIMs is not limited to interpreting SVMs, but is applicable to general k−mer based scoring systems.

Web [BibTex]

Sonnenburg, S., Zien, A., Philips, P., Rätsch, G. Positional Oligomer Importance Matrices NIPS Workshop on Machine Learning in Computational Biology, December 2007 (talk)

Web [BibTex]

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Machine Learning Algorithms for Polymorphism Detection

Schweikert, G., Zeller, G., Weigel, D., Schölkopf, B., Rätsch, G.

NIPS Workshop on Machine Learning in Computational Biology, December 2007 (talk)

Web [BibTex]

Schweikert, G., Zeller, G., Weigel, D., Schölkopf, B., Rätsch, G. Machine Learning Algorithms for Polymorphism Detection NIPS Workshop on Machine Learning in Computational Biology, December 2007 (talk)

Web [BibTex]

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An Automated Combination of Kernels for Predicting Protein Subcellular Localization

Zien, A., Ong, C.

NIPS Workshop on Machine Learning in Computational Biology, December 2007 (talk)

Abstract
Protein subcellular localization is a crucial ingredient to many important inferences about cellular processes, including prediction of protein function and protein interactions.We propose a new class of protein sequence kernels which considers all motifs including motifs with gaps. This class of kernels allows the inclusion of pairwise amino acid distances into their computation. We utilize an extension of the multiclass support vector machine (SVM)method which directly solves protein subcellular localization without resorting to the common approach of splitting the problem into several binary classification problems. To automatically search over families of possible amino acid motifs, we optimize over multiple kernels at the same time. We compare our automated approach to four other predictors on three different datasets, and show that we perform better than the current state of the art. Furthermore, our method provides some insights as to which features are most useful for determining subcellular localization, which are in agreement with biological reasoning.

Web [BibTex]

Zien, A., Ong, C. An Automated Combination of Kernels for Predicting Protein Subcellular Localization NIPS Workshop on Machine Learning in Computational Biology, December 2007 (talk)

Web [BibTex]

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Challenges in Brain-Computer Interface Development: Induction, Measurement, Decoding, Integration

Hill, NJ.

Invited keynote talk at the launch of BrainGain, the Dutch BCI research consortium, November 2007 (talk)

Abstract
I‘ll present a perspective on Brain-Computer Interface development from T{\"u}bingen. Some of the benefits promised by BCI technology lie in the near foreseeable future, and some further away. Our motivation is to make BCI technology feasible for the people who could benefit from what it has to offer soon: namely, people in the "completely locked-in" state. I‘ll mention some of the challenges of working with this user group, and explain the specific directions they have motivated us to take in developing experimental methods, algorithms, and software.

[BibTex]

Hill, NJ. Challenges in Brain-Computer Interface Development: Induction, Measurement, Decoding, Integration Invited keynote talk at the launch of BrainGain, the Dutch BCI research consortium, November 2007 (talk)

[BibTex]

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Some Theoretical Aspects of Human Categorization Behavior: Similarity and Generalization

Jäkel, F.

Biologische Kybernetik, Eberhard-Karls-Universität Tübingen, Tübingen, Germany, November 2007, passed with "ausgezeichnet", summa cum laude, published online (phdthesis)

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Jäkel, F. Some Theoretical Aspects of Human Categorization Behavior: Similarity and Generalization Biologische Kybernetik, Eberhard-Karls-Universität Tübingen, Tübingen, Germany, November 2007, passed with "ausgezeichnet", summa cum laude, published online (phdthesis)

PDF [BibTex]

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Statistical Learning Theory Approaches to Clustering

Jegelka, S.

Biologische Kybernetik, Eberhard-Karls-Universität Tübingen, Tübingen, Germany, November 2007 (diplomathesis)

PDF [BibTex]

Jegelka, S. Statistical Learning Theory Approaches to Clustering Biologische Kybernetik, Eberhard-Karls-Universität Tübingen, Tübingen, Germany, November 2007 (diplomathesis)

PDF [BibTex]

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Policy Learning for Robotics

Peters, J.

14th International Conference on Neural Information Processing (ICONIP), November 2007 (talk)

Web [BibTex]

Peters, J. Policy Learning for Robotics 14th International Conference on Neural Information Processing (ICONIP), November 2007 (talk)

Web [BibTex]

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Hilbert Space Representations of Probability Distributions

Gretton, A.

2nd Workshop on Machine Learning and Optimization at the ISM, October 2007 (talk)

Abstract
Many problems in unsupervised learning require the analysis of features of probability distributions. At the most fundamental level, we might wish to determine whether two distributions are the same, based on samples from each - this is known as the two-sample or homogeneity problem. We use kernel methods to address this problem, by mapping probability distributions to elements in a reproducing kernel Hilbert space (RKHS). Given a sufficiently rich RKHS, these representations are unique: thus comparing feature space representations allows us to compare distributions without ambiguity. Applications include testing whether cancer subtypes are distinguishable on the basis of DNA microarray data, and whether low frequency oscillations measured at an electrode in the cortex have a different distribution during a neural spike. A more difficult problem is to discover whether two random variables drawn from a joint distribution are independent. It turns out that any dependence between pairs of random variables can be encoded in a cross-covariance operator between appropriate RKHS representations of the variables, and we may test independence by looking at a norm of the operator. We demonstrate this independence test by establishing dependence between an English text and its French translation, as opposed to French text on the same topic but otherwise unrelated. Finally, we show that this operator norm is itself a difference in feature means.

PDF Web [BibTex]

Gretton, A. Hilbert Space Representations of Probability Distributions 2nd Workshop on Machine Learning and Optimization at the ISM, October 2007 (talk)

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Regression with Intervals

Kashima, H., Yamazaki, K., Saigo, H., Inokuchi, A.

International Workshop on Data-Mining and Statistical Science (DMSS2007), October 2007, JSAI Incentive Award. Talk was given by Hisashi Kashima. (talk)

Web [BibTex]

Kashima, H., Yamazaki, K., Saigo, H., Inokuchi, A. Regression with Intervals International Workshop on Data-Mining and Statistical Science (DMSS2007), October 2007, JSAI Incentive Award. Talk was given by Hisashi Kashima. (talk)

Web [BibTex]

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MR-Based PET Attenuation Correction: Method and Validation

Hofmann, M., Steinke, F., Scheel, V., Brady, M., Schölkopf, B., Pichler, B.

Joint Molecular Imaging Conference, September 2007 (talk)

Abstract
PET/MR combines the high soft tissue contrast of Magnetic Resonance Imaging (MRI) and the functional information of Positron Emission Tomography (PET). For quantitative PET information, correction of tissue photon attenuation is mandatory. Usually in conventional PET, the attenuation map is obtained from a transmission scan, which uses a rotating source, or from the CT scan in case of combined PET/CT. In the case of a PET/MR scanner, there is insufficient space for the rotating source and ideally one would want to calculate the attenuation map from the MR image instead. Since MR images provide information about proton density of the different tissue types, it is not trivial to use this data for PET attenuation correction. We present a method for predicting the PET attenuation map from a given the MR image, using a combination of atlas-registration and recognition of local patterns. Using "leave one out cross validation" we show on a database of 16 MR-CT image pairs that our method reliably allows estimating the CT image from the MR image. Subsequently, as in PET/CT, the PET attenuation map can be predicted from the CT image. On an additional dataset of MR/CT/PET triplets we quantitatively validate that our approach allows PET quantification with an error that is smaller than what would be clinically significant. We demonstrate our approach on T1-weighted human brain scans. However, the presented methods are more general and current research focuses on applying the established methods to human whole body PET/MRI applications.

PDF Web [BibTex]

Hofmann, M., Steinke, F., Scheel, V., Brady, M., Schölkopf, B., Pichler, B. MR-Based PET Attenuation Correction: Method and Validation Joint Molecular Imaging Conference, September 2007 (talk)

PDF Web [BibTex]

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Predicting Structured Data

Bakir, G., Hofmann, T., Schölkopf, B., Smola, A., Taskar, B., Vishwanathan, S.

pages: 360, Advances in neural information processing systems, MIT Press, Cambridge, MA, USA, September 2007 (book)

Abstract
Machine learning develops intelligent computer systems that are able to generalize from previously seen examples. A new domain of machine learning, in which the prediction must satisfy the additional constraints found in structured data, poses one of machine learning’s greatest challenges: learning functional dependencies between arbitrary input and output domains. This volume presents and analyzes the state of the art in machine learning algorithms and theory in this novel field. The contributors discuss applications as diverse as machine translation, document markup, computational biology, and information extraction, among others, providing a timely overview of an exciting field.

Web [BibTex]

Bakir, G., Hofmann, T., Schölkopf, B., Smola, A., Taskar, B., Vishwanathan, S. Predicting Structured Data pages: 360, Advances in neural information processing systems, MIT Press, Cambridge, MA, USA, September 2007 (book)

Web [BibTex]

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Bayesian methods for NMR structure determination

Habeck, M.

29th Annual Discussion Meeting: Magnetic Resonance in Biophysical Chemistry, September 2007 (talk)

Web [BibTex]

Habeck, M. Bayesian methods for NMR structure determination 29th Annual Discussion Meeting: Magnetic Resonance in Biophysical Chemistry, September 2007 (talk)

Web [BibTex]

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Thinking Out Loud: Research and Development of Brain Computer Interfaces

Hill, NJ.

Invited keynote talk at the Max Planck Society‘s PhDNet Workshop., July 2007 (talk)

Abstract
My principal interest is in applying machine-learning methods to the development of Brain-Computer Interfaces (BCI). This involves the classification of a user‘s intentions or mental states, or regression against some continuous intentional control signal, using brain signals obtained for example by EEG, ECoG or MEG. The long-term aim is to develop systems that a completely paralysed person (such as someone suffering from advanced Amyotrophic Lateral Sclerosis) could use to communicate. Such systems have the potential to improve the lives of many people who would be otherwise completely unable to communicate, but they are still very much in the research and development stages.

PDF [BibTex]

Hill, NJ. Thinking Out Loud: Research and Development of Brain Computer Interfaces Invited keynote talk at the Max Planck Society‘s PhDNet Workshop., July 2007 (talk)

PDF [BibTex]

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Error Correcting Codes for the P300 Visual Speller

Biessmann, F.

Biologische Kybernetik, Eberhard-Karls-Universität Tübingen, Tübingen, Germany, July 2007 (diplomathesis)

Abstract
The aim of brain-computer interface (BCI) research is to establish a communication system based on intentional modulation of brain activity. This is accomplished by classifying patterns of brain ac- tivity, volitionally induced by the user. The BCI presented in this study is based on a classical paradigm as proposed by (Farwell and Donchin, 1988), the P300 visual speller. Recording electroencephalo- grams (EEG) from the scalp while presenting letters successively to the user, the speller can infer from the brain signal which letter the user was focussing on. Since EEG recordings are noisy, usually many repetitions are needed to detect the correct letter. The focus of this study was to improve the accuracy of the visual speller applying some basic principles from information theory: Stimulus sequences of the speller have been modified into error-correcting codes. Additionally a language model was incorporated into the probabilistic letter de- coder. Classification of single EEG epochs was less accurate using error correcting codes. However, the novel code could compensate for that such that overall, letter accuracies were as high as or even higher than for classical stimulus codes. In particular at high noise levels, error-correcting decoding achieved higher letter accuracies.

PDF [BibTex]

Biessmann, F. Error Correcting Codes for the P300 Visual Speller Biologische Kybernetik, Eberhard-Karls-Universität Tübingen, Tübingen, Germany, July 2007 (diplomathesis)

PDF [BibTex]

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Dirichlet Process Mixtures of Factor Analysers

Görür, D., Rasmussen, C.

Fifth Workshop on Bayesian Inference in Stochastic Processes (BSP5), June 2007 (talk)

Abstract
Mixture of factor analysers (MFA) is a well-known model that combines the dimensionality reduction technique of Factor Analysis (FA) with mixture modeling. The key issue in MFA is deciding on the latent dimension and the number of mixture components to be used. The Bayesian treatment of MFA has been considered by Beal and Ghahramani (2000) using variational approximation and by Fokoué and Titterington (2003) using birth-and –death Markov chain Monte Carlo (MCMC). Here, we present the nonparametric MFA model utilizing a Dirichlet process (DP) prior on the component parameters (that is, the factor loading matrix and the mean vector of each component) and describe an MCMC scheme for inference. The clustering property of the DP provides automatic selection of the number of mixture components. The latent dimensionality of each component is inferred by automatic relevance determination (ARD). Identifying the action potentials of individual neurons from extracellular recordings, known as spike sorting, is a challenging clustering problem. We apply our model for clustering the waveforms recorded from the cortex of a macaque monkey.

Web [BibTex]

Görür, D., Rasmussen, C. Dirichlet Process Mixtures of Factor Analysers Fifth Workshop on Bayesian Inference in Stochastic Processes (BSP5), June 2007 (talk)

Web [BibTex]

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New BCI approaches: Selective Attention to Auditory and Tactile Stimulus Streams

Hill, N., Raths, C.

Invited talk at the PASCAL Workshop on Methods of Data Analysis in Computational Neuroscience and Brain Computer Interfaces, June 2007 (talk)

Abstract
When considering Brain-Computer Interface (BCI) development for patients in the most severely paralysed states, there is considerable motivation to move away from BCI systems based on either motor cortex activity, or on visual stimuli. Together these account for most of current BCI research. I present the results of our recent exploration of new auditory- and tactile-stimulus-driven BCIs. The talk includes a tutorial on the construction and interpretation of classifiers which extract spatio-temporal features from event-related potential data. The effects and implications of whitening are discussed, and preliminary results on the effectiveness of a low-rank constraint (Tomioka and Aihara 2007) are shown.

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Hill, N., Raths, C. New BCI approaches: Selective Attention to Auditory and Tactile Stimulus Streams Invited talk at the PASCAL Workshop on Methods of Data Analysis in Computational Neuroscience and Brain Computer Interfaces, June 2007 (talk)

PDF Web [BibTex]

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Towards Motor Skill Learning in Robotics

Peters, J.

Interactive Robot Learning - RSS workshop, June 2007 (talk)

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Peters, J. Towards Motor Skill Learning in Robotics Interactive Robot Learning - RSS workshop, June 2007 (talk)

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Transductive Support Vector Machines for Structured Variables

Zien, A., Brefeld, U., Scheffer, T.

International Conference on Machine Learning (ICML), June 2007 (talk)

Abstract
We study the problem of learning kernel machines transductively for structured output variables. Transductive learning can be reduced to combinatorial optimization problems over all possible labelings of the unlabeled data. In order to scale transductive learning to structured variables, we transform the corresponding non-convex, combinatorial, constrained optimization problems into continuous, unconstrained optimization problems. The discrete optimization parameters are eliminated and the resulting differentiable problems can be optimized efficiently. We study the effectiveness of the generalized TSVM on multiclass classification and label-sequence learning problems empirically.

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Zien, A., Brefeld, U., Scheffer, T. Transductive Support Vector Machines for Structured Variables International Conference on Machine Learning (ICML), June 2007 (talk)

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Impact of target-to-target interval on classification performance in the P300 speller

Martens, S., Hill, J., Farquhar, J., Schölkopf, B.

Scientific Meeting "Applied Neuroscience for Healthy Brain Function", May 2007 (talk)

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Martens, S., Hill, J., Farquhar, J., Schölkopf, B. Impact of target-to-target interval on classification performance in the P300 speller Scientific Meeting "Applied Neuroscience for Healthy Brain Function", May 2007 (talk)

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Nonparametric Bayesian Discrete Latent Variable Models for Unsupervised Learning

Görür, D.

Biologische Kybernetik, Technische Universität Berlin, Berlin, Germany, April 2007, published online (phdthesis)

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Görür, D. Nonparametric Bayesian Discrete Latent Variable Models for Unsupervised Learning Biologische Kybernetik, Technische Universität Berlin, Berlin, Germany, April 2007, published online (phdthesis)

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Applications of Kernel Machines to Structured Data

Eichhorn, J.

Biologische Kybernetik, Technische Universität Berlin, Berlin, Germany, March 2007, passed with "sehr gut", published online (phdthesis)

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Eichhorn, J. Applications of Kernel Machines to Structured Data Biologische Kybernetik, Technische Universität Berlin, Berlin, Germany, March 2007, passed with "sehr gut", published online (phdthesis)

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