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The genome of the simian and human malaria parasite Plasmodium knowlesi

2008

Article

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Plasmodium knowlesi is an intracellular malaria parasite whose natural vertebrate host is Macaca fascicularis (the 'kra' monkey); however, it is now increasingly recognized as a significant cause of human malaria, particularly in southeast Asia1, 2. Plasmodium knowlesi was the first malaria parasite species in which antigenic variation was demonstrated3, and it has a close phylogenetic relationship to Plasmodium vivax 4, the second most important species of human malaria parasite (reviewed in ref. 4). Despite their relatedness, there are important phenotypic differences between them, such as host blood cell preference, absence of a dormant liver stage or 'hypnozoite' in P. knowlesi, and length of the asexual cycle (reviewed in ref. 4). Here we present an analysis of the P. knowlesi (H strain, Pk1(A+) clone5) nuclear genome sequence. This is the first monkey malaria parasite genome to be described, and it provides an opportunity for comparison with the recently completed P. vivax genome4 and other sequenced Plasmodium genomes6, 7, 8. In contrast to other Plasmodium genomes, putative variant antigen families are dispersed throughout the genome and are associated with intrachromosomal telomere repeats. One of these families, the KIRs9, contains sequences that collectively match over one-half of the host CD99 extracellular domain, which may represent an unusual form of molecular mimicry.

Author(s): Pain, A. and Böhme, U. and Berry, AE. and Mungall, K. and Finn, RD. and Jackson, AP. and Mourier, T. and Mistry, J. and Pasini, EM. and Aslett, MA. and Balasubrammaniam, S. and Borgwardt, K. and Brooks, K. and Carret, C. and Carver, TJ. and Cherevach, I. and Chillingworth, T. and Clarke, T. and Galinski, MR. and Hall, N. and Harper, D. and Harris, D. and Hauser, H. and Ivens, A. and Janssen, CS. and Keane, T. and Larke, N. and Lapp, S. and Marti, M. and Moule, S. and Meyer, IM. and Ormond, D. and Peters, N. and Sanders, M. and Sanders, T. and Sergeant, TJ. and Simmonds, M. and Smith, F. and Squares, R. and Thurston, S. and Tivey, AR. and Walker, D. and White, B. and Zuiderwijk, E. and Churcher, C. and Quail, MA. and Cowman, AF. and Turner, CMR. and Rajandream, MA. and Kocken, CHM. and Thomas, AW. and Newbold, C. and Barrell, BG. and Berriman, M.
Journal: Nature
Volume: 455
Number (issue): 7214
Pages: 799-803
Year: 2008
Month: October
Day: 0

Department(s): Empirical Inference
Bibtex Type: Article (article)

Digital: 0
DOI: 10.1038/nature07306

Links: PDF

BibTex

@article{PainBBMFJMMPABBBCCCCCGHHHHIJKLLMMMOPSSSSSSTTWWZCQCTRKTNBB2008,
  title = {The genome of the simian and human malaria parasite Plasmodium knowlesi},
  author = {Pain, A. and B{\"o}hme, U. and Berry, AE. and Mungall, K. and Finn, RD. and Jackson, AP. and Mourier, T. and Mistry, J. and Pasini, EM. and Aslett, MA. and Balasubrammaniam, S. and Borgwardt, K. and Brooks, K. and Carret, C. and Carver, TJ. and Cherevach, I. and Chillingworth, T. and Clarke, T. and Galinski, MR. and Hall, N. and Harper, D. and Harris, D. and Hauser, H. and Ivens, A. and Janssen, CS. and Keane, T. and Larke, N. and Lapp, S. and Marti, M. and Moule, S. and Meyer, IM. and Ormond, D. and Peters, N. and Sanders, M. and Sanders, T. and Sergeant, TJ. and Simmonds, M. and Smith, F. and Squares, R. and Thurston, S. and Tivey, AR. and Walker, D. and White, B. and Zuiderwijk, E. and Churcher, C. and Quail, MA. and Cowman, AF. and Turner, CMR. and Rajandream, MA. and Kocken, CHM. and Thomas, AW. and Newbold, C. and Barrell, BG. and Berriman, M.},
  journal = {Nature},
  volume = {455},
  number = {7214},
  pages = {799-803},
  month = oct,
  year = {2008},
  month_numeric = {10}
}