Header logo is ei

Microarrays: How Many Do You Need?

2002

Conference Paper

ei


We estimate the number of microarrays that is required in order to gain reliable results from a common type of study: the pairwise comparison of different classes of samples. Current knowlegde seems to suffice for the construction of models that are realistic with respect to searches for individual differentially expressed genes. Such models allow to investigate the dependence of the required number of samples on the relevant parameters: the biological variability of the samples within each class; the fold changes in expression; the detection sensitivity of the microarrays; and the acceptable error rates of the results. We supply experimentalists with general conclusions as well as a freely accessible Java applet at http://cartan.gmd.de/~zien/classsize/ for fine tuning simulations to their particular actualities. Since the situation can be assumed to be very similar for large scale proteomics and metabolomics studies, our methods and results might also apply there.

Author(s): Zien, A. and Fluck, J. and Zimmer, R. and Lengauer, T.
Book Title: RECOMB 2002
Journal: Proceedings of the Sixth Annual International Conference on Research in Computational Molecular Biology (RECOMB 2002)
Pages: 321-330
Year: 2002
Month: April
Day: 0
Publisher: ACM Press

Department(s): Empirical Inference
Bibtex Type: Conference Paper (inproceedings)

DOI: 10.1145/565196.565239
Event Name: Sixth Annual International Conference on Research in Computational Molecular Biology
Event Place: Washington, DC, USA

Address: New York, NY, USA
Digital: 0
Institution: Fraunhofer Institute SCAI
Language: en
Organization: Max-Planck-Gesellschaft
School: Biologische Kybernetik

Links: Web

BibTex

@inproceedings{2144,
  title = {Microarrays: How Many Do You Need?},
  author = {Zien, A. and Fluck, J. and Zimmer, R. and Lengauer, T.},
  journal = {Proceedings of the Sixth Annual International Conference on Research in Computational Molecular Biology (RECOMB 2002)},
  booktitle = {RECOMB 2002},
  pages = {321-330},
  publisher = {ACM Press},
  organization = {Max-Planck-Gesellschaft},
  institution = {Fraunhofer Institute SCAI},
  school = {Biologische Kybernetik},
  address = {New York, NY, USA},
  month = apr,
  year = {2002},
  month_numeric = {4}
}