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Analysis of multiparametric MRI using a semi-supervised random forest framework allows the detection of therapy response in ischemic stroke

Castaneda, S., Katiyar, P., Russo, F., Calaminus, C., Disselhorst, J. A., Ziemann, U., Kohlhofer, U., Quintanilla-Martinez, L., Poli, S., Pichler, B. J.

World Molecular Imaging Conference, 2016 (talk)

link (url) [BibTex]

link (url) [BibTex]


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Painfree and accurate Bayesian estimation of psychometric functions for (potentially) overdispersed data

Schütt, H. H., Harmeling, S., Macke, J. H., Wichmann, F. A.

Vision Research, 122, pages: 105-123, 2016 (article)

link (url) DOI Project Page [BibTex]

link (url) DOI Project Page [BibTex]


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A cognitive brain–computer interface for patients with amyotrophic lateral sclerosis

Hohmann, M., Fomina, T., Jayaram, V., Widmann, N., Förster, C., Just, J., Synofzik, M., Schölkopf, B., Schöls, L., Grosse-Wentrup, M.

In Brain-Computer Interfaces: Lab Experiments to Real-World Applications, 228(Supplement C):221-239, 8, Progress in Brain Research, (Editors: Damien Coyle), Elsevier, 2016 (incollection)

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Hierarchical Relative Entropy Policy Search

Daniel, C., Neumann, G., Kroemer, O., Peters, J.

Journal of Machine Learning Research, 17(93):1-50, 2016 (article)

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Kernel Mean Shrinkage Estimators

Muandet, K., Sriperumbudur, B., Fukumizu, K., Gretton, A., Schölkopf, B.

Journal of Machine Learning Research, 17(48):1-41, 2016 (article)

link (url) [BibTex]

link (url) [BibTex]


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Learning to Deblur

Schuler, C. J., Hirsch, M., Harmeling, S., Schölkopf, B.

IEEE Transactions on Pattern Analysis and Machine Intelligence, 38(7):1439-1451, IEEE, 2016 (article)

DOI [BibTex]

DOI [BibTex]


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Transfer Learning in Brain-Computer Interfaces

Jayaram, V., Alamgir, M., Altun, Y., Schölkopf, B., Grosse-Wentrup, M.

IEEE Computational Intelligence Magazine, 11(1):20-31, 2016 (article)

PDF DOI [BibTex]

PDF DOI [BibTex]


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MERLiN: Mixture Effect Recovery in Linear Networks

Weichwald, S., Grosse-Wentrup, M., Gretton, A.

IEEE Journal of Selected Topics in Signal Processing, 10(7):1254-1266, 2016 (article)

Arxiv Code PDF DOI Project Page [BibTex]

Arxiv Code PDF DOI Project Page [BibTex]


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Causal inference using invariant prediction: identification and confidence intervals

Peters, J., Bühlmann, P., Meinshausen, N.

Journal of the Royal Statistical Society, Series B (Statistical Methodology), 78(5):947-1012, 2016, (with discussion) (article)

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Causal discovery and inference: concepts and recent methodological advances

Spirtes, P., Zhang, K.

Applied Informatics, 3(3):1-28, 2016 (article)

DOI [BibTex]

DOI [BibTex]


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Multiparametric Imaging of Ischemic Stroke using [89Zr]-Desferal-EPO-PET/MRI in combination with Gaussian Mixture Modeling enables unsupervised lesions identification

Castaneda, S., Katiyar, P., Russo, F., Maurer, A., Patzwaldt, K., Poli, S., Calaminus, C., Disselhorst, J. A., Ziemann, U., Pichler, B. J.

European Molecular Imaging Meeting, 2016 (poster)

link (url) [BibTex]

link (url) [BibTex]


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Influence Estimation and Maximization in Continuous-Time Diffusion Networks

Gomez-Rodriguez, M., Song, L., Du, N., Zha, H., Schölkopf, B.

ACM Transactions on Information Systems, 34(2):9:1-9:33, 2016 (article)

DOI Project Page Project Page [BibTex]

DOI Project Page Project Page [BibTex]


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Modeling Variability of Musculoskeletal Systems with Heteroscedastic Gaussian Processes

Büchler, D., Calandra, R., Peters, J.

Workshop on Neurorobotics, Neural Information Processing Systems (NIPS), 2016 (conference)

NIPS16Neurorobotics [BibTex]

NIPS16Neurorobotics [BibTex]


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The population of long-period transiting exoplanets

Foreman-Mackey, D., Morton, T. D., Hogg, D. W., Agol, E., Schölkopf, B.

The Astronomical Journal, 152(6):206, 2016 (article)

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Statistical source separation of rhythmic LFP patterns during sharp wave ripples in the macaque hippocampus

Ramirez-Villegas, J. F., Logothetis, N. K., Besserve, M.

47th Annual Meeting of the Society for Neuroscience (Neuroscience), 2016 (poster)

[BibTex]

[BibTex]


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Screening Rules for Convex Problems

Raj, A., Olbrich, J., Gärtner, B., Schölkopf, B., Jaggi, M.

2016 (unpublished) Submitted

[BibTex]

[BibTex]


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An overview of quantitative approaches in Gestalt perception

Jäkel, F., Singh, M., Wichmann, F. A., Herzog, M. H.

Vision Research, 126, pages: 3-8, 2016 (article)

link (url) DOI Project Page [BibTex]

link (url) DOI Project Page [BibTex]


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Causal and statistical learning

Schölkopf, B., Janzing, D., Lopez-Paz, D.

Oberwolfach Reports, 13(3):1896-1899, (Editors: A. Christmann and K. Jetter and S. Smale and D.-X. Zhou), 2016 (conference)

DOI [BibTex]

DOI [BibTex]


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Bootstrat: Population Informed Bootstrapping for Rare Variant Tests

Huang, H., Peloso, G. M., Howrigan, D., Rakitsch, B., Simon-Gabriel, C. J., Goldstein, J. I., Daly, M. J., Borgwardt, K., Neale, B. M.

bioRxiv, 2016, preprint (article)

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Probabilistic Movement Models Show that Postural Control Precedes and Predicts Volitional Motor Control

Rueckert, E., Camernik, J., Peters, J., Babic, J.

Nature PG: Scientific Reports, 6(Article number: 28455), 2016 (article)

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Learning Taxonomy Adaptation in Large-scale Classification

Babbar, R., Partalas, I., Gaussier, E., Amini, M., Amblard, C.

Journal of Machine Learning Research, 17(98):1-37, 2016 (article)

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Multi-view learning on multiparametric PET/MRI quantifies intratumoral heterogeneity and determines therapy efficacy

Katiyar, P., Divine, M. R., Kohlhofer, U., Quintanilla-Martinez, L., Siegemund, M., Pfizenmaier, K., Kontermann, R., Pichler, B. J., Disselhorst, J. A.

World Molecular Imaging Conference, 2016 (talk)

link (url) [BibTex]

link (url) [BibTex]


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Hippocampal neural events predict ongoing brain-wide BOLD activity

Besserve, M., Logothetis, N. K.

47th Annual Meeting of the Society for Neuroscience (Neuroscience), 2016 (poster)

[BibTex]

[BibTex]


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BOiS—Berlin Object in Scene Database: Controlled Photographic Images for Visual Search Experiments with Quantified Contextual Priors

Mohr, J., Seyfarth, J., Lueschow, A., Weber, J. E., Wichmann, F. A., Obermayer, K.

Frontiers in Psychology, 2016 (article)

DOI [BibTex]

DOI [BibTex]


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Preface to the ACM TIST Special Issue on Causal Discovery and Inference

Zhang, K., Li, J., Bareinboim, E., Schölkopf, B., Pearl, J.

ACM Transactions on Intelligent Systems and Technologies, 7(2):article no. 17, 2016 (article)

DOI [BibTex]

DOI [BibTex]


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Recurrent Spiking Networks Solve Planning Tasks

Rueckert, E., Kappel, D., Tanneberg, D., Pecevski, D., Peters, J.

Nature PG: Scientific Reports, 6(Article number: 21142), 2016 (article)

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Bio-inspired feedback-circuit implementation of discrete, free energy optimizing, winner-take-all computations

Genewein, T, Braun, DA

Biological Cybernetics, 110(2):135–150, June 2016 (article)

Abstract
Bayesian inference and bounded rational decision-making require the accumulation of evidence or utility, respectively, to transform a prior belief or strategy into a posterior probability distribution over hypotheses or actions. Crucially, this process cannot be simply realized by independent integrators, since the different hypotheses and actions also compete with each other. In continuous time, this competitive integration process can be described by a special case of the replicator equation. Here we investigate simple analog electric circuits that implement the underlying differential equation under the constraint that we only permit a limited set of building blocks that we regard as biologically interpretable, such as capacitors, resistors, voltage-dependent conductances and voltage- or current-controlled current and voltage sources. The appeal of these circuits is that they intrinsically perform normalization without requiring an explicit divisive normalization. However, even in idealized simulations, we find that these circuits are very sensitive to internal noise as they accumulate error over time. We discuss in how far neural circuits could implement these operations that might provide a generic competitive principle underlying both perception and action.

DOI [BibTex]

DOI [BibTex]


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Decision-Making under Ambiguity Is Modulated by Visual Framing, but Not by Motor vs. Non-Motor Context: Experiments and an Information-Theoretic Ambiguity Model

Grau-Moya, J, Ortega, PA, Braun, DA

PLoS ONE, 11(4):1-21, April 2016 (article)

Abstract
A number of recent studies have investigated differences in human choice behavior depending on task framing, especially comparing economic decision-making to choice behavior in equivalent sensorimotor tasks. Here we test whether decision-making under ambiguity exhibits effects of task framing in motor vs. non-motor context. In a first experiment, we designed an experience-based urn task with varying degrees of ambiguity and an equivalent motor task where subjects chose between hitting partially occluded targets. In a second experiment, we controlled for the different stimulus design in the two tasks by introducing an urn task with bar stimuli matching those in the motor task. We found ambiguity attitudes to be mainly influenced by stimulus design. In particular, we found that the same subjects tended to be ambiguity-preferring when choosing between ambiguous bar stimuli, but ambiguity-avoiding when choosing between ambiguous urn sample stimuli. In contrast, subjects’ choice pattern was not affected by changing from a target hitting task to a non-motor context when keeping the stimulus design unchanged. In both tasks subjects’ choice behavior was continuously modulated by the degree of ambiguity. We show that this modulation of behavior can be explained by an information-theoretic model of ambiguity that generalizes Bayes-optimal decision-making by combining Bayesian inference with robust decision-making under model uncertainty. Our results demonstrate the benefits of information-theoretic models of decision-making under varying degrees of ambiguity for a given context, but also demonstrate the sensitivity of ambiguity attitudes across contexts that theoretical models struggle to explain.

DOI [BibTex]

2014


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Modeling the polygenic architecture of complex traits

Rakitsch, Barbara

Eberhard Karls Universität Tübingen, November 2014 (phdthesis)

[BibTex]

2014

[BibTex]


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Human Pose Estimation with Fields of Parts

Kiefel, M., Gehler, P.

In Computer Vision – ECCV 2014, LNCS 8693, pages: 331-346, Lecture Notes in Computer Science, (Editors: Fleet, David and Pajdla, Tomas and Schiele, Bernt and Tuytelaars, Tinne), Springer, 13th European Conference on Computer Vision, September 2014 (inproceedings)

Abstract
This paper proposes a new formulation of the human pose estimation problem. We present the Fields of Parts model, a binary Conditional Random Field model designed to detect human body parts of articulated people in single images. The Fields of Parts model is inspired by the idea of Pictorial Structures, it models local appearance and joint spatial configuration of the human body. However the underlying graph structure is entirely different. The idea is simple: we model the presence and absence of a body part at every possible position, orientation, and scale in an image with a binary random variable. This results into a vast number of random variables, however, we show that approximate inference in this model is efficient. Moreover we can encode the very same appearance and spatial structure as in Pictorial Structures models. This approach allows us to combine ideas from segmentation and pose estimation into a single model. The Fields of Parts model can use evidence from the background, include local color information, and it is connected more densely than a kinematic chain structure. On the challenging Leeds Sports Poses dataset we improve over the Pictorial Structures counterpart by 5.5% in terms of Average Precision of Keypoints (APK).

website pdf DOI Project Page [BibTex]

website pdf DOI Project Page [BibTex]


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Probabilistic Progress Bars

Kiefel, M., Schuler, C., Hennig, P.

In Conference on Pattern Recognition (GCPR), 8753, pages: 331-341, Lecture Notes in Computer Science, (Editors: Jiang, X., Hornegger, J., and Koch, R.), Springer, GCPR, September 2014 (inproceedings)

Abstract
Predicting the time at which the integral over a stochastic process reaches a target level is a value of interest in many applications. Often, such computations have to be made at low cost, in real time. As an intuitive example that captures many features of this problem class, we choose progress bars, a ubiquitous element of computer user interfaces. These predictors are usually based on simple point estimators, with no error modelling. This leads to fluctuating behaviour confusing to the user. It also does not provide a distribution prediction (risk values), which are crucial for many other application areas. We construct and empirically evaluate a fast, constant cost algorithm using a Gauss-Markov process model which provides more information to the user.

website+code pdf DOI [BibTex]

website+code pdf DOI [BibTex]


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Seeing the Arrow of Time

Pickup, L., Zheng, P., Donglai, W., YiChang, S., Changshui, Z., Zisserman, A., Schölkopf, B., Freeman, W.

Computer Vision and Pattern Recognition (CVPR), 2014 IEEE Conference on, pages: 2043-2050, IEEE, CVPR, June 2014 (conference)

DOI [BibTex]

DOI [BibTex]


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Probabilistic Solutions to Differential Equations and their Application to Riemannian Statistics

Hennig, P., Hauberg, S.

In Proceedings of the 17th International Conference on Artificial Intelligence and Statistics, 33, pages: 347-355, JMLR: Workshop and Conference Proceedings, (Editors: S Kaski and J Corander), Microtome Publishing, Brookline, MA, AISTATS, April 2014 (inproceedings)

Abstract
We study a probabilistic numerical method for the solution of both boundary and initial value problems that returns a joint Gaussian process posterior over the solution. Such methods have concrete value in the statistics on Riemannian manifolds, where non-analytic ordinary differential equations are involved in virtually all computations. The probabilistic formulation permits marginalising the uncertainty of the numerical solution such that statistics are less sensitive to inaccuracies. This leads to new Riemannian algorithms for mean value computations and principal geodesic analysis. Marginalisation also means results can be less precise than point estimates, enabling a noticeable speed-up over the state of the art. Our approach is an argument for a wider point that uncertainty caused by numerical calculations should be tracked throughout the pipeline of machine learning algorithms.

pdf Youtube Supplements Project page link (url) [BibTex]

pdf Youtube Supplements Project page link (url) [BibTex]


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Method and device for blind correction of optical aberrations in a digital image

Schuler, C., Hirsch, M., Harmeling, S., Schölkopf, B.

International Patent Application, No. PCT/EP2012/068868, April 2014 (patent)

[BibTex]


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A Visual Analytics Approach to Study Anatomic Covariation

Hermann, M., Schunke, A., Schultz, T., Klein, R.

In Proceedings of IEEE Pacific Visualization 2014, pages: 161-168, March 2014 (inproceedings)

Abstract
Gaining insight into anatomic covariation helps the understanding of organismic shape variability in general and is of particular interest for delimiting morphological modules. Generation of hypotheses on structural covariation is undoubtedly a highly creative process, and as such, requires an exploratory approach. In this work we propose a new local anatomic covariance tensor which enables interactive visualizations to explore covariation at different levels of detail, stimulating rapid formation and (qualitative) evaluation of hypotheses. The effectiveness of the presented approach is demonstrated on a muCT dataset of mouse mandibles for which results from the literature are successfully reproduced, while providing a more detailed representation of covariation compared to state-of-the-art methods.

PDF DOI [BibTex]

PDF DOI [BibTex]


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Juggling revisited — A voxel based morphometry study with expert jugglers

Gerber, P., Schlaffke, L., Heba, S., Greenlee, M., Schultz, T., Schmidt-Wilcke, T.

NeuroImage, 95, pages: 320-325, 2014 (article)

Web DOI [BibTex]

Web DOI [BibTex]


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Assessing attention and cognitive function in completely locked-in state with event-related brain potentials and epidural electrocorticography

Bensch, M., Martens, S., Halder, S., Hill, J., Nijboer, F., Ramos, A., Birbaumer, N., Bodgan, M., Kotchoubey, B., Rosenstiel, W., Schölkopf, B., Gharabaghi, A.

Journal of Neural Engineering, 11(2):026006, 2014 (article)

Abstract
Objective. Patients in the completely locked-in state (CLIS), due to, for example, amyotrophic lateral sclerosis (ALS), no longer possess voluntary muscle control. Assessing attention and cognitive function in these patients during the course of the disease is a challenging but essential task for both nursing staff and physicians. Approach. An electrophysiological cognition test battery, including auditory and semantic stimuli, was applied in a late-stage ALS patient at four different time points during a six-month epidural electrocorticography (ECoG) recording period. Event-related cortical potentials (ERP), together with changes in the ECoG signal spectrum, were recorded via 128 channels that partially covered the left frontal, temporal and parietal cortex. Main results. Auditory but not semantic stimuli induced significant and reproducible ERP projecting to specific temporal and parietal cortical areas. N1/P2 responses could be detected throughout the whole study period. The highest P3 ERP was measured immediately after the patient's last communication through voluntary muscle control, which was paralleled by low theta and high gamma spectral power. Three months after the patient's last communication, i.e., in the CLIS, P3 responses could no longer be detected. At the same time, increased activity in low-frequency bands and a sharp drop of gamma spectral power were recorded. Significance. Cortical electrophysiological measures indicate at least partially intact attention and cognitive function during sparse volitional motor control for communication. Although the P3 ERP and frequency-specific changes in the ECoG spectrum may serve as indicators for CLIS, a close-meshed monitoring will be required to define the exact time point of the transition.

DOI [BibTex]

DOI [BibTex]


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Identifiability of Gaussian Structural Equation Models with Equal Error Variances

Peters, J., Bühlman, P.

Biometrika, 101(1):219-228, 2014 (article)

DOI [BibTex]


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Dynamical source analysis of hippocampal sharp-wave ripple episodes

Ramirez-Villegas, J. F., Logothetis, N. K., Besserve, M.

Bernstein Conference, 2014 (poster)

DOI [BibTex]

DOI [BibTex]


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Quantifying the effect of intertrial dependence on perceptual decisions

Fründ, I., Wichmann, F., Macke, J.

Journal of Vision, 14(7):1-16, 2014 (article)

Web PDF link (url) DOI [BibTex]


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Two numerical models designed to reproduce Saturn ring temperatures as measured by Cassini-CIRS

Altobelli, N., Lopez-Paz, D., Pilorz, S., Spilker, L., Morishima, R., Brooks, S., Leyrat, C., Deau, E., Edgington, S., Flandes, A.

Icarus, 238(0):205 - 220, 2014 (article)

Web link (url) DOI [BibTex]

Web link (url) DOI [BibTex]