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1998


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Funktionelle Magnetresonanztomographie in der psychopathologischen Forschung.

Spitzer, M., Kammer, T., Bellemann, M., Brix, G., Layer, B., Maier, S., Kischka, U., Gückel, F.

Fortschritte der Neurologie Psychiatrie, 66, pages: 241-258, 1998 (article)

Abstract
Mental disorders are characterised by psychopathological symptoms which correspond to functional brain states. Functional magnetic resonance imaging (fMRI) is used for the non-invasive study of cerebral activation patterns in man. First of all, the neurobiological principles and presuppositions of the method are outlined. Results from the Heidelberg imaging lab on several simple sensorimotor tasks as well as higher cognitive functions, such as working and semantic memory, are then presented. Thereafter, results from preliminary fMRI studies of psychopathological symptoms are discussed, with emphasis on hallucinations, psychomotoric phenomena, emotions, as well as obsessions and compulsions. Functional MRI is limited by the physics underlying the method, as well as by practical constraints regarding its use in conjunction with mentally ill patients. Within this framework, the problems of signal-to-noise ratio, data analysis strategies, motion correction, and neurovascular coupling are considered. Because of the rapid development of the field of fMRI, maps of higher cognitive functions and their respective pathology seem to be coming within easy reach.

[BibTex]

1998

[BibTex]

1997


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Comparing support vector machines with Gaussian kernels to radial basis function classifiers

Schölkopf, B., Sung, K., Burges, C., Girosi, F., Niyogi, P., Poggio, T., Vapnik, V.

IEEE Transactions on Signal Processing, 45(11):2758-2765, November 1997 (article)

Abstract
The support vector (SV) machine is a novel type of learning machine, based on statistical learning theory, which contains polynomial classifiers, neural networks, and radial basis function (RBF) networks as special cases. In the RBF case, the SV algorithm automatically determines centers, weights, and threshold that minimize an upper bound on the expected test error. The present study is devoted to an experimental comparison of these machines with a classical approach, where the centers are determined by X-means clustering, and the weights are computed using error backpropagation. We consider three machines, namely, a classical RBF machine, an SV machine with Gaussian kernel, and a hybrid system with the centers determined by the SV method and the weights trained by error backpropagation. Our results show that on the United States postal service database of handwritten digits, the SV machine achieves the highest recognition accuracy, followed by the hybrid system. The SV approach is thus not only theoretically well-founded but also superior in a practical application.

Web DOI [BibTex]

1997

Web DOI [BibTex]


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ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

Vaziri, H., MD, .., RC, .., Davison, T., YS, .., CH, .., GG, .., Benchimol, S.

The European Molecular Biology Organization Journal, 16(19):6018-6033, 1997 (article)

Web [BibTex]

Web [BibTex]