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2013


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Explicit eigenvalues of certain scaled trigonometric matrices

Sra, S.

Linear Algebra and its Applications, 438(1):173-181, January 2013 (article)

DOI [BibTex]

2013

DOI [BibTex]


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How Sensitive Is the Human Visual System to the Local Statistics of Natural Images?

Gerhard, H., Wichmann, F., Bethge, M.

PLoS Computational Biology, 9(1):e1002873, January 2013 (article)

Abstract
Several aspects of primate visual physiology have been identified as adaptations to local regularities of natural images. However, much less work has measured visual sensitivity to local natural image regularities. Most previous work focuses on global perception of large images and shows that observers are more sensitive to visual information when image properties resemble those of natural images. In this work we measure human sensitivity to local natural image regularities using stimuli generated by patch-based probabilistic natural image models that have been related to primate visual physiology. We find that human observers can learn to discriminate the statistical regularities of natural image patches from those represented by current natural image models after very few exposures and that discriminability depends on the degree of regularities captured by the model. The quick learning we observed suggests that the human visual system is biased for processing natural images, even at very fine spatial scales, and that it has a surprisingly large knowledge of the regularities in natural images, at least in comparison to the state-of-the-art statistical models of natural images.

DOI [BibTex]

DOI [BibTex]


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A neural population model for visual pattern detection

Goris, R., Putzeys, T., Wagemans, J., Wichmann, F.

Psychological Review, 120(3):472–496, 2013 (article)

DOI [BibTex]

DOI [BibTex]


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Accurate indel prediction using paired-end short reads

Grimm, D., Hagmann, J., Koenig, D., Weigel, D., Borgwardt, KM.

BMC Genomics, 14(132), 2013 (article)

Web DOI [BibTex]

Web DOI [BibTex]


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Counterfactual Reasoning and Learning Systems: The Example of Computational Advertising

Bottou, L., Peters, J., Quiñonero-Candela, J., Charles, D., Chickering, D., Portugualy, E., Ray, D., Simard, P., Snelson, E.

Journal of Machine Learning Research, 14, pages: 3207-3260, 2013 (article)

Web link (url) [BibTex]

Web link (url) [BibTex]


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When luminance increment thresholds depend on apparent lightness

Maertens, M., Wichmann, F.

Journal of Vision, 13(6):1-11, 2013 (article)

DOI [BibTex]

DOI [BibTex]


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Efficient network-guided multi-locus association mapping with graph cuts

Azencott, C., Grimm, D., Sugiyama, M., Kawahara, Y., Borgwardt, K.

Bioinformatics, 29(13):i171-i179, 2013 (article)

DOI [BibTex]

DOI [BibTex]


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Quantifying causal influences

Janzing, D., Balduzzi, D., Grosse-Wentrup, M., Schölkopf, B.

Annals of Statistics, 41(5):2324-2358, 2013 (article)

Web [BibTex]

Web [BibTex]


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Probabilistic movement modeling for intention inference in human-robot interaction

Wang, Z., Mülling, K., Deisenroth, M., Ben Amor, H., Vogt, D., Schölkopf, B., Peters, J.

International Journal of Robotics Research, 32(7):841-858, 2013 (article)

PDF DOI [BibTex]

PDF DOI [BibTex]


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Blind Retrospective Motion Correction of MR Images

Loktyushin, A., Nickisch, H., Pohmann, R., Schölkopf, B.

Magnetic Resonance in Medicine (MRM), 70(6):1608–1618, 2013 (article)

DOI [BibTex]

DOI [BibTex]


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Modeling fixation locations using spatial point processes

Barthelmé, S., Trukenbrod, H., Engbert, R., Wichmann, F.

Journal of Vision, 13(12):1-34, 2013 (article)

Abstract
Whenever eye movements are measured, a central part of the analysis has to do with where subjects fixate and why they fixated where they fixated. To a first approximation, a set of fixations can be viewed as a set of points in space; this implies that fixations are spatial data and that the analysis of fixation locations can be beneficially thought of as a spatial statistics problem. We argue that thinking of fixation locations as arising from point processes is a very fruitful framework for eye-movement data, helping turn qualitative questions into quantitative ones. We provide a tutorial introduction to some of the main ideas of the field of spatial statistics, focusing especially on spatial Poisson processes. We show how point processes help relate image properties to fixation locations. In particular we show how point processes naturally express the idea that image features' predictability for fixations may vary from one image to another. We review other methods of analysis used in the literature, show how they relate to point process theory, and argue that thinking in terms of point processes substantially extends the range of analyses that can be performed and clarify their interpretation.

Web DOI [BibTex]

Web DOI [BibTex]


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A probabilistic model for secondary structure prediction from protein chemical shifts

Mechelke, M., Habeck, M.

Proteins: Structure, Function, and Bioinformatics, 81(6):984–993, 2013 (article)

DOI [BibTex]

DOI [BibTex]


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Climate Extremes and the Carbon Cycle

Reichstein, M., Bahn, M., Ciais, P., Frank, D., Mahecha, M., Seneviratne, S., Zscheischler, J., Beer, C., Buchmann, N., Frank, D., Papale, D., Rammig, A., Smith, P., Thonicke, K., van der Velde, M., Vicca, S., Walz, A., Wattenbach, M.

Nature, 500, pages: 287-295, 2013 (article)

DOI [BibTex]

DOI [BibTex]


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Identification of stimulus cues in narrow-band tone-in-noise detection using sparse observer models

Schönfelder, V., Wichmann, F.

Journal of the Acoustical Society of America, 134(1):447-463, 2013 (article)

DOI [BibTex]

DOI [BibTex]


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Probabilistic Model-based Imitation Learning

Englert, P., Paraschos, A., Peters, J., Deisenroth, M.

Adaptive Behavior Journal, 21(5):388-403, 2013 (article)

PDF DOI [BibTex]

PDF DOI [BibTex]


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Metabolic cost as an organizing principle for cooperative learning

Balduzzi, D., Ortega, P., Besserve, M.

Advances in Complex Systems, 16(02n03):1350012, 2013 (article)

Web DOI [BibTex]

Web DOI [BibTex]


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MR-based PET Attenuation Correction for PET/MR Imaging

Bezrukov, I., Mantlik, F., Schmidt, H., Schölkopf, B., Pichler, B.

Seminars in Nuclear Medicine, 43(1):45-59, 2013 (article)

DOI [BibTex]

DOI [BibTex]


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MR-based Attenuation Correction Methods for Improved PET Quantification in Lesions within Bone and Susceptibility Artifact Regions

Bezrukov, I., Schmidt, H., Mantlik, F., Schwenzer, N., Brendle, C., Schölkopf, B., Pichler, B.

Journal of Nuclear Medicine, 54(10):1768-1774, 2013 (article)

Abstract
Hybrid PET/MR systems have recently entered clinical practice. Thus, the accuracy of MR-based attenuation correction in simultaneously acquired data can now be investigated. We assessed the accuracy of 4 methods of MR-based attenuation correction in lesions within soft tissue, bone, and MR susceptibility artifacts: 2 segmentation-based methods (SEG1, provided by the manufacturer, and SEG2, a method with atlas-based susceptibility artifact correction); an atlas- and pattern recognition–based method (AT&PR), which also used artifact correction; and a new method combining AT&PR and SEG2 (SEG2wBONE). Methods: Attenuation maps were calculated for the PET/MR datasets of 10 patients acquired on a whole-body PET/MR system, allowing for simultaneous acquisition of PET and MR data. Eighty percent iso-contour volumes of interest were placed on lesions in soft tissue (n = 21), in bone (n = 20), near bone (n = 19), and within or near MR susceptibility artifacts (n = 9). Relative mean volume-of-interest differences were calculated with CT-based attenuation correction as a reference. Results: For soft-tissue lesions, none of the methods revealed a significant difference in PET standardized uptake value relative to CT-based attenuation correction (SEG1, −2.6% ± 5.8%; SEG2, −1.6% ± 4.9%; AT&PR, −4.7% ± 6.5%; SEG2wBONE, 0.2% ± 5.3%). For bone lesions, underestimation of PET standardized uptake values was found for all methods, with minimized error for the atlas-based approaches (SEG1, −16.1% ± 9.7%; SEG2, −11.0% ± 6.7%; AT&PR, −6.6% ± 5.0%; SEG2wBONE, −4.7% ± 4.4%). For lesions near bone, underestimations of lower magnitude were observed (SEG1, −12.0% ± 7.4%; SEG2, −9.2% ± 6.5%; AT&PR, −4.6% ± 7.8%; SEG2wBONE, −4.2% ± 6.2%). For lesions affected by MR susceptibility artifacts, quantification errors could be reduced using the atlas-based artifact correction (SEG1, −54.0% ± 38.4%; SEG2, −15.0% ± 12.2%; AT&PR, −4.1% ± 11.2%; SEG2wBONE, 0.6% ± 11.1%). Conclusion: For soft-tissue lesions, none of the evaluated methods showed statistically significant errors. For bone lesions, significant underestimations of −16% and −11% occurred for methods in which bone tissue was ignored (SEG1 and SEG2). In the present attenuation correction schemes, uncorrected MR susceptibility artifacts typically result in reduced attenuation values, potentially leading to highly reduced PET standardized uptake values, rendering lesions indistinguishable from background. While AT&PR and SEG2wBONE show accurate results in both soft tissue and bone, SEG2wBONE uses a two-step approach for tissue classification, which increases the robustness of prediction and can be applied retrospectively if more precision in bone areas is needed.

Web DOI [BibTex]

Web DOI [BibTex]


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Learning output kernels for multi-task problems

Dinuzzo, F.

Neurocomputing, 118, pages: 119-126, 2013 (article)

DOI [BibTex]

DOI [BibTex]


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Analytical probabilistic modeling for radiation therapy treatment planning

Bangert, M., Hennig, P., Oelfke, U.

Physics in Medicine and Biology, 58(16):5401-5419, 2013 (article)

PDF DOI [BibTex]

PDF DOI [BibTex]


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Imaging Findings and Therapy Response Monitoring in Chronic Sclerodermatous Graft-Versus-Host Disease: Preliminary Data of a Simultaneous PET/MRI Approach

Sauter, A., Schmidt, H., Mantlik, F., Kolb, A., Federmann, B., Pfannenberg, C., Reimold, M., Pichler, B., Bethge, W., Horger, M.

Clinical Nuclear Medicine, 38(8):e309-e317, 2013 (article)

Abstract
PURPOSE: Our objective was a multifunctional imaging approach of chronic sclerodermatous graft-versus-host disease (ScGVHD) and its course during therapy using PET/MRI. METHODS: We performed partial-body PET/CT and PET/MRI of the calf in 6 consecutively recruited patients presenting with severe ScGVHD. The patients were treated with different immunosuppressive regimens and supportive therapies. PET/CT scanning started 60.5 +/- 3.3 minutes, PET/MRI imaging 139.5 +/- 16.7 minutes after F-FDG application. MRI acquisition included T1- (precontrast and postcontrast) and T2-weighted sequences. SUVmean, T1 contrast enhancement, and T2 signal intensity from region-of-interest analysis were calculated for different fascial and muscular compartments. In addition, musculoskeletal MRI findings and the modified Rodnan skin score were assessed. All patients underwent imaging follow-up. RESULTS: At baseline PET/MRI, ScGVHD-related musculoskeletal abnormalities consisted of increased signal and/or thickening of involved anatomical structures on T2-weighted and T1 postcontrast images as well as an increased FDG uptake. At follow-up, ScGVHD-related imaging findings decreased (SUVmean n = 4, mean T1 contrast enhancement n = 5, mean T2 signal intensity n = 3) or progressed (SUVmean n = 3, mean T1 contrast enhancement n = 2, mean T2 signal intensity n = 4). Clinically modified Rodnan skin score improved for 5 follow-ups and progressed for 2. SUVmean values correlated between PET/CT and PET/MRI acquisition (r = 0.660, P = 0.014), T1 contrast enhancement, and T2 signal (r = 0.668, P = 0.012), but not between the SUVmean values and the MRI parameters. CONCLUSIONS: PET/MRI as a combined morphological and functional technique seems to assess the inflammatory processes from different points of view and provides therefore in part complementary information

Web [BibTex]

Web [BibTex]


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A Survey on Policy Search for Robotics, Foundations and Trends in Robotics

Deisenroth, M., Neumann, G., Peters, J.

Foundations and Trends in Robotics, 2(1-2):1-142, 2013 (article)

DOI [BibTex]

DOI [BibTex]


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Reinforcement Learning in Robotics: A Review

Kober, J., Bagnell, D., Peters, J.

International Journal of Robotics Research, 32(11):1238–1274, 2013 (article)

PDF DOI [BibTex]

PDF DOI [BibTex]


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Multimodal information improves the rapid detection of mental fatigue

Laurent, F., Valderrama, M., Besserve, M., Guillard, M., Lachaux, J., Martinerie, J., Florence, G.

Biomedical Signal Processing and Control, 8(4):400 - 408, 2013 (article)

Web DOI [BibTex]

Web DOI [BibTex]


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Interactive Domain Adaptation for the Classification of Remote Sensing Images using Active Learning

Persello, C.

IEEE Geoscience and Remote Sensing Letters, 10(4):736-740, 2013 (article)

DOI [BibTex]


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Learning to Select and Generalize Striking Movements in Robot Table Tennis

Mülling, K., Kober, J., Kroemer, O., Peters, J.

International Journal of Robotics Research, 32(3):263-279, 2013 (article)

PDF DOI [BibTex]


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HiFiVE: A Hilbert Space Embedding of Fiber Variability Estimates for Uncertainty Modeling and Visualization

Schultz, T., Schlaffke, L., Schölkopf, B., Schmidt-Wilcke, T.

Computer Graphics Forum, 32(3):121-130, (Editors: B Preim, P Rheingans, and H Theisel), Blackwell Publishing, Oxford, UK, Eurographics Conference on Visualization (EuroVis), 2013 (article)

DOI [BibTex]

DOI [BibTex]


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Detection and attribution of large spatiotemporal extreme events in Earth observation data

Zscheischler, J., Mahecha, M., Harmeling, S., Reichstein, M.

Ecological Informatics, 15, pages: 66-73, 2013 (article)

Abstract
Latest climate projections suggest that both frequency and intensity of climate extremes will be substantially modified over the course of the coming decades. As a consequence, we need to understand to what extent and via which pathways climate extremes affect the state and functionality of terrestrial ecosystems and the associated biogeochemical cycles on a global scale. So far the impacts of climate extremes on the terrestrial biosphere were mainly investigated on the basis of case studies, while global assessments are widely lacking. In order to facilitate global analysis of this kind, we present a methodological framework that firstly detects spatiotemporally contiguous extremes in Earth observations, and secondly infers the likely pathway of the preceding climate anomaly. The approach does not require long time series, is computationally fast, and easily applicable to a variety of data sets with different spatial and temporal resolutions. The key element of our analysis strategy is to directly search in the relevant observations for spatiotemporally connected components exceeding a certain percentile threshold. We also put an emphasis on characterization of extreme event distribution, and scrutinize the attribution issue. We exemplify the analysis strategy by exploring the fraction of absorbed photosynthetically active radiation (fAPAR) from 1982 to 2011. Our results suggest that the hot spots of extremes in fAPAR lie in Northeastern Brazil, Southeastern Australia, Kenya and Tanzania. Moreover, we demonstrate that the size distribution of extremes follow a distinct power law. The attribution framework reveals that extremes in fAPAR are primarily driven by phases of water scarcity.

Web DOI [BibTex]

Web DOI [BibTex]


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Simultaneous PET/MR reveals Brain Function in Activated and Resting State on Metabolic, Hemodynamic and Multiple Temporal Scales

Wehrl, H., Hossain, M., Lankes, K., Liu, C., Bezrukov, I., Martirosian, P., Schick, F., Reischl, G., Pichler, B.

Nature Medicine, 19, pages: 1184–1189, 2013 (article)

Abstract
Combined positron emission tomography (PET) and magnetic resonance imaging (MRI) is a new tool to study functional processes in the brain. Here we study brain function in response to a barrel-field stimulus simultaneously using PET, which traces changes in glucose metabolism on a slow time scale, and functional MRI (fMRI), which assesses fast vascular and oxygenation changes during activation. We found spatial and quantitative discrepancies between the PET and the fMRI activation data. The functional connectivity of the rat brain was assessed by both modalities: the fMRI approach determined a total of nine known neural networks, whereas the PET method identified seven glucose metabolism–related networks. These results demonstrate the feasibility of combined PET-MRI for the simultaneous study of the brain at activation and rest, revealing comprehensive and complementary information to further decode brain function and brain networks.

Web DOI [BibTex]

Web DOI [BibTex]


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Domain Generalization via Invariant Feature Representation

Muandet, K.

30th International Conference on Machine Learning (ICML2013), 2013 (talk)

PDF [BibTex]

PDF [BibTex]


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Finding Potential Support Vectors in Separable Classification Problems

Varagnolo, D., Del Favero, S., Dinuzzo, F., Schenato, L., Pillonetto, G.

IEEE Transactions on Neural Networks and Learning Systems, 24(11):1799-1813, 2013 (article)

DOI [BibTex]

DOI [BibTex]


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Open-Box Spectral Clustering: Applications to Medical Image Analysis

Schultz, T., Kindlmann, G.

IEEE Transactions on Visualization and Computer Graphics, 19(12):2100-2108, 2013 (article)

DOI [BibTex]

DOI [BibTex]


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im3shape: a maximum likelihood galaxy shear measurement code for cosmic gravitational lensing

Zuntz, J., Kacprzak, T., Voigt, L., Hirsch, M., Rowe, B., Bridle, S.

Monthly Notices of the Royal Astronomical Society, 434(2):1604-1618, Oxford University Press, 2013 (article)

DOI [BibTex]

DOI [BibTex]


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Accurate detection of differential RNA processing

Drewe, P., Stegle, O., Hartmann, L., Kahles, A., Bohnert, R., Wachter, A., Borgwardt, K. M., Rätsch, G.

Nucleic Acids Research, 41(10):5189-5198, 2013 (article)

DOI [BibTex]

DOI [BibTex]


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Detecting regulatory gene–environment interactions with unmeasured environmental factors

Fusi, N., Lippert, C., Borgwardt, K. M., Lawrence, N. D., Stegle, O.

Bioinformatics, 29(11):1382-1389, 2013 (article)

DOI [BibTex]

DOI [BibTex]


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Fragmentation of Slow Wave Sleep after Onset of Complete Locked-In State

Soekadar, S. R., Born, J., Birbaumer, N., Bensch, M., Halder, S., Murguialday, A. R., Gharabaghi, A., Nijboer, F., Schölkopf, B., Martens, S.

Journal of Clinical Sleep Medicine, 9(9):951-953, 2013 (article)

DOI [BibTex]

DOI [BibTex]


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Structural learning

Braun, D

Scholarpedia, 8(10):12312, October 2013 (article)

Abstract
Structural learning in motor control refers to a metalearning process whereby an agent extracts (abstract) invariants from its sensorimotor stream when experiencing a range of environments that share similar structure. Such invariants can then be exploited for faster generalization and learning-to-learn when experiencing novel, but related task environments.

DOI [BibTex]

DOI [BibTex]


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The effect of model uncertainty on cooperation in sensorimotor interactions

Grau-Moya, J, Hez, E, Pezzulo, G, Braun, DA

Journal of the Royal Society Interface, 10(87):1-11, October 2013 (article)

Abstract
Decision-makers have been shown to rely on probabilistic models for perception and action. However, these models can be incorrect or partially wrong in which case the decision-maker has to cope with model uncertainty. Model uncertainty has recently also been shown to be an important determinant of sensorimotor behaviour in humans that can lead to risk-sensitive deviations from Bayes optimal behaviour towards worst-case or best-case outcomes. Here, we investigate the effect of model uncertainty on cooperation in sensorimotor interactions similar to the stag-hunt game, where players develop models about the other player and decide between a pay-off-dominant cooperative solution and a risk-dominant, non-cooperative solution. In simulations, we show that players who allow for optimistic deviations from their opponent model are much more likely to converge to cooperative outcomes. We also implemented this agent model in a virtual reality environment, and let human subjects play against a virtual player. In this game, subjects' pay-offs were experienced as forces opposing their movements. During the experiment, we manipulated the risk sensitivity of the computer player and observed human responses. We found not only that humans adaptively changed their level of cooperation depending on the risk sensitivity of the computer player but also that their initial play exhibited characteristic risk-sensitive biases. Our results suggest that model uncertainty is an important determinant of cooperation in two-player sensorimotor interactions.

DOI [BibTex]

DOI [BibTex]


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Thermodynamics as a theory of decision-making with information-processing costs

Ortega, PA, Braun, DA

Proceedings of the Royal Society of London A, 469(2153):1-18, May 2013 (article)

Abstract
Perfectly rational decision-makers maximize expected utility, but crucially ignore the resource costs incurred when determining optimal actions. Here, we propose a thermodynamically inspired formalization of bounded rational decision-making where information processing is modelled as state changes in thermodynamic systems that can be quantified by differences in free energy. By optimizing a free energy, bounded rational decision-makers trade off expected utility gains and information-processing costs measured by the relative entropy. As a result, the bounded rational decision-making problem can be rephrased in terms of well-known variational principles from statistical physics. In the limit when computational costs are ignored, the maximum expected utility principle is recovered. We discuss links to existing decision-making frameworks and applications to human decision-making experiments that are at odds with expected utility theory. Since most of the mathematical machinery can be borrowed from statistical physics, the main contribution is to re-interpret the formalism of thermodynamic free-energy differences in terms of bounded rational decision-making and to discuss its relationship to human decision-making experiments.

DOI [BibTex]

DOI [BibTex]

2007


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HPLC analysis and pharmacokinetic study of quercitrin and isoquercitrin in rat plasma after administration of Hypericum japonicum thunb. extract.

Li, J., Wang, W., Zhang, L., Chen, H., Bi, S.

Biomedical Chromatography, 22(4):374-378, December 2007 (article)

Abstract
A simple HPLC method was developed for determination of quercitrin and isoquercitrin in rat plasma. Reversed-phase HPLC was employed for the quantitative analysis using kaempferol-3-O--d-glucopyranoside-7-O--l-rhamnoside as an internal standard. Following extraction from the plasma samples with ethyl acetate-isopropanol (95:5, v/v), these two compounds were successfully separated on a Luna C18 column (250 × 4.6 mm, 5 µm) with isocratic elution of acetonitrile-0.5% aqueous acetic acid (17:83, v/v) as the mobile phase. The flow-rate was set at 1 mL/min and the eluent was detected at 350 nm for both quercitrin and isoquercitrin. The method was linear over the studied ranges of 50-6000 and 50-5000 ng/mL for quercitrin and isoquercitrin, respectively. The intra- and inter-day precisions of the analysis were better than 13.1 and 13.2%, respectively. The lower limits of quantitation for quercitrin and isoquercitrin in plasma were both of 50 ng/mL. The mean extraction recoveries were 73 and 61% for quercitrin and i soquercitrin, respectively. The validated method was successfully applied to pharmacokinetic studies of the two analytes in rat plasma after the oral administration of Hypericum japonicum thunb. ethanol extract.

Web DOI [BibTex]


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Reaction graph kernels for discovering missing enzymes in the plant secondary metabolism

Saigo, H., Hattori, M., Tsuda, K.

NIPS Workshop on Machine Learning in Computational Biology, December 2007 (talk)

Abstract
Secondary metabolic pathway in plant is important for finding druggable candidate enzymes. However, there are many enzymes whose functions are still undiscovered especially in organism-specific metabolic pathways. We propose reaction graph kernels for automatically assigning the EC numbers to unknown enzymatic reactions in a metabolic network. Experiments are carried out on KEGG/REACTION database and our method successfully predicted the first three digits of the EC number with 83% accuracy.We also exhaustively predicted missing enzymatic functions in the plant secondary metabolism pathways, and evaluated our results in biochemical validity.

Web [BibTex]

Web [BibTex]


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Positional Oligomer Importance Matrices

Sonnenburg, S., Zien, A., Philips, P., Rätsch, G.

NIPS Workshop on Machine Learning in Computational Biology, December 2007 (talk)

Abstract
At the heart of many important bioinformatics problems, such as gene finding and function prediction, is the classification of biological sequences, above all of DNA and proteins. In many cases, the most accurate classifiers are obtained by training SVMs with complex sequence kernels, for instance for transcription starts or splice sites. However, an often criticized downside of SVMs with complex kernels is that it is very hard for humans to understand the learned decision rules and to derive biological insights from them. To close this gap, we introduce the concept of positional oligomer importance matrices (POIMs) and develop an efficient algorithm for their computation. We demonstrate how they overcome the limitations of sequence logos, and how they can be used to find relevant motifs for different biological phenomena in a straight-forward way. Note that the concept of POIMs is not limited to interpreting SVMs, but is applicable to general k−mer based scoring systems.

Web [BibTex]

Web [BibTex]


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Machine Learning Algorithms for Polymorphism Detection

Schweikert, G., Zeller, G., Weigel, D., Schölkopf, B., Rätsch, G.

NIPS Workshop on Machine Learning in Computational Biology, December 2007 (talk)

Web [BibTex]

Web [BibTex]


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Graph sharpening plus graph integration: a synergy that improves protein functional classification

Shin, HH., Lisewski, AM., Lichtarge, O.

Bioinformatics, 23(23):3217-3224, December 2007 (article)

Web DOI [BibTex]

Web DOI [BibTex]


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A Tutorial on Spectral Clustering

von Luxburg, U.

Statistics and Computing, 17(4):395-416, December 2007 (article)

Abstract
In recent years, spectral clustering has become one of the most popular modern clustering algorithms. It is simple to implement, can be solved efficiently by standard linear algebra software, and very often outperforms traditional clustering algorithms such as the k-means algorithm. On the first glance spectral clustering appears slightly mysterious, and it is not obvious to see why it works at all and what it really does. The goal of this tutorial is to give some intuition on those questions. We describe different graph Laplacians and their basic properties, present the most common spectral clustering algorithms, and derive those algorithms from scratch by several different approaches. Advantages and disadvantages of the different spectral clustering algorithms are discussed.

PDF PDF DOI [BibTex]

PDF PDF DOI [BibTex]


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An Automated Combination of Kernels for Predicting Protein Subcellular Localization

Zien, A., Ong, C.

NIPS Workshop on Machine Learning in Computational Biology, December 2007 (talk)

Abstract
Protein subcellular localization is a crucial ingredient to many important inferences about cellular processes, including prediction of protein function and protein interactions.We propose a new class of protein sequence kernels which considers all motifs including motifs with gaps. This class of kernels allows the inclusion of pairwise amino acid distances into their computation. We utilize an extension of the multiclass support vector machine (SVM)method which directly solves protein subcellular localization without resorting to the common approach of splitting the problem into several binary classification problems. To automatically search over families of possible amino acid motifs, we optimize over multiple kernels at the same time. We compare our automated approach to four other predictors on three different datasets, and show that we perform better than the current state of the art. Furthermore, our method provides some insights as to which features are most useful for determining subcellular localization, which are in agreement with biological reasoning.

Web [BibTex]

Web [BibTex]


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A Tutorial on Kernel Methods for Categorization

Jäkel, F., Schölkopf, B., Wichmann, F.

Journal of Mathematical Psychology, 51(6):343-358, December 2007 (article)

Abstract
The abilities to learn and to categorize are fundamental for cognitive systems, be it animals or machines, and therefore have attracted attention from engineers and psychologists alike. Modern machine learning methods and psychological models of categorization are remarkably similar, partly because these two fields share a common history in artificial neural networks and reinforcement learning. However, machine learning is now an independent and mature field that has moved beyond psychologically or neurally inspired algorithms towards providing foundations for a theory of learning that is rooted in statistics and functional analysis. Much of this research is potentially interesting for psychological theories of learning and categorization but also hardly accessible for psychologists. Here, we provide a tutorial introduction to a popular class of machine learning tools, called kernel methods. These methods are closely related to perceptrons, radial-basis-function neural networks and exemplar theories of catego rization. Recent theoretical advances in machine learning are closely tied to the idea that the similarity of patterns can be encapsulated in a positive definite kernel. Such a positive definite kernel can define a reproducing kernel Hilbert space which allows one to use powerful tools from functional analysis for the analysis of learning algorithms. We give basic explanations of some key concepts—the so-called kernel trick, the representer theorem and regularization—which may open up the possibility that insights from machine learning can feed back into psychology.

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


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A semigroup approach to queueing systems

Haji, A., Radl, A.

Semigroup Forum, 75(3):610-624, December 2007 (article)

Abstract
We prove asymptotic stability of the solutions of equations describing a simple queueing system consisting of two machines separated by a finite storage buffer. Following an approach by G. Gupur, we apply the theory of C0-semigroups and spectral theory of positive operators.

PDF DOI [BibTex]

PDF DOI [BibTex]